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Dietary Intake of n-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and Lipoprotein Particle Size

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Dietary Intake of n-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and Lipoprotein Particle Size

dc.contributor.author	Lai, Chao-Qiang
dc.contributor.author	Corella, Dolores
dc.contributor.author	Demissie, Serkalem
dc.contributor.author	Cupples, L. Adrienne
dc.contributor.author	Adiconis, Xian
dc.contributor.author	Yueping, Zhu
dc.contributor.author	Parnell, Laurence D.
dc.contributor.author	Tucker, Katherine L.
dc.contributor.author	Ordovas, Jose M.
dc.date.accessioned	2011-06-02T09:29:34Z
dc.date.available	2011-06-02T09:29:34Z
dc.date.issued	2006
dc.identifier.citation	LAI, Chao-Qiang ; Corella Piquer, Maria Dolores ; Demissie, Serkalem ; Cupples, L. Adrienne ; Adiconis, Xian ; Yueping, Zhu ; Parnell, Laurence D. ; Tucker, Katherine L. ; Ordovas, Jose M., 2006, Dietary Intake of n-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and Lipoprotein Particle Size, Circulation, vol. 113, no. 17, p. 2062-2070	en
dc.identifier.uri	http://hdl.handle.net/10550/18832
dc.description.abstract	Background— Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association. Methods and Results— We investigated the interaction between APOA5 gene variation and dietary fat in determining plasma fasting TGs, remnant-like particle (RLP) concentrations, and lipoprotein particle size in 1001 men and 1147 women who were Framingham Heart Study participants. Polymorphisms –1131T>C and 56C>G, representing 2 independent haplotypes, were analyzed. Significant gene–diet interactions between the –1131T>C polymorphism and polyunsaturated fatty acid (PUFA) intake were found (P<0.001) in determining fasting TGs, RLP concentrations, and particle size, but these interactions were not found for the 56C>G polymorphism. The –1131C allele was associated with higher fasting TGs and RLP concentrations (P<0.01) in only the subjects consuming a high-PUFA diet (>6% of total energy). No heterogeneity by sex was found. These interactions showed a dose-response effect when PUFA intake was considered as a continuous variable (P<0.01). Similar interactions were found for the sizes of VLDL and LDL particles. Only in carriers of the –1131C allele did the size of these particles increase (VLDL) or decrease (LDL) as PUFA intake increased (P<0.01). We further analyzed the effects of n-6 and n-3 fatty acids and found that the PUFA–APOA5 interactions were specific for dietary n-6 fatty acids. Conclusions— Higher n-6 (but not n-3) PUFA intake increased fasting TGs, RLP concentrations, and VLDL size and decreased LDL size in APOA5 –1131C carriers, suggesting that n-6 PUFA–rich diets are related to a more atherogenic lipid profile in these subjects.	en
dc.language.iso	en	en
dc.subject	Diet ; Fatty acids ; Genetics ; Lipids ; Lipoproteins	en
dc.title	Dietary Intake of n-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and Lipoprotein Particle Size	en
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS ::Medicina interna	en
dc.identifier.doi	10.1161/CIRCULATIONAHA.105.577296	en
dc.identifier.idgrec	036548	en
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://circ.ahajournals.org/cgi/reprint/113/17/2062	en