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Accumulation of symetric dimethylarginine in hepatorenal syndrome.

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Accumulation of symetric dimethylarginine in hepatorenal syndrome.

dc.contributor.author	Lluch García, Paloma
dc.contributor.author	Mauricio Aviñó, María Dolores
dc.contributor.author	Vila Salinas, José María
dc.contributor.author	Segarra Irles, Gloria Vicenta
dc.contributor.author	Medina Bessó, Pascual
dc.contributor.author	Olmo Puchalt, Juan Angel del
dc.contributor.author	Rodrigo Gómez, José Manuel
dc.contributor.author	Serra Desfilis, Miguel Ángel
dc.date.accessioned	2013-11-22T10:58:27Z
dc.date.available	2013-11-22T10:58:27Z
dc.date.issued	2006
dc.identifier.citation	Lluch García, Paloma Mauricio Aviño, María Dolores Vila Salinas, José Maria Segarra Irles, Gloria Vicenta Medina Besso, Pascual Olmo Puchalt, Juan Angel del Rodrigo Gómez, José Manuel Serra Desfilis, Miguel Angel 2006 Accumulation of symetric dimethylarginine in hepatorenal syndrome. Experimental Biology and Medicine 231 70 75
dc.identifier.uri	http://hdl.handle.net/10550/31336
dc.description.abstract	In patients with cirrhosis, nitric oxide (NO), asymmetric dimethylarginine (ADMA), and possibly symmetric dimethylarginine (SDMA) have been linked to the severity of the disease. We investigated whether plasma levels of dimethylarginines and NO are elevated in patients with hepatorenal syndrome (HRS), compared with patients with cirrhosis without renal failure (no- HRS). Plasma levels of NO, ADMA, SDMA, and L-arginine were measured in 11 patients with HRS, seven patients with no-HRS, and six healthy volunteers. SDMA concentration in HRS was higher than in no-HRS and healthy subjects (1.47 6 0.25 vs. 0.38 6 0.06 and 0.29 6 0.04 lM, respectively; P , 0.05). ADMA and NOx concentrations were higher in HRS and no-HRS patients than in healthy subjects (ADMA, 1.20 6 0.26, 1.11 6 0.1, and 0.53 6 0.06 lM, respectively; P , 0.05; NOx, 94 6 9.1, 95.5 6 9.54, and 37.67 6 4.62 lM, respectively; P , 0.05). In patients with HRS there was a positive correlation between serum creatinine and plasma SDMA (r2¼0.765, P , 0.001) but not between serum creatinine and ADMA or NOx. The results suggest that renal dysfunction is a main determinant of elevated SDMA concentration in HRS. Accumulation of ADMA as a result of impaired hepatic removal may be the causative factor initiating renal vasoconstriction and SDMA retention in the kidney. Exp Biol Med 231:70<br>75, 2006
dc.relation.ispartof	Experimental Biology and Medicine, 2006, vol. 231, p. 70-75
dc.subject	Medicina
dc.subject	Patologia
dc.title	Accumulation of symetric dimethylarginine in hepatorenal syndrome.
dc.type	journal article	es_ES
dc.date.updated	2013-11-22T10:58:27Z
dc.identifier.idgrec	022493
dc.rights.accessRights	open access	es_ES