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Serum antibodies to Vibrio vulnificus biotype 3 lipopolysaccharide and susceptibility to disease caused by the homologous V. vulnificus biotype

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Serum antibodies to Vibrio vulnificus biotype 3 lipopolysaccharide and susceptibility to disease caused by the homologous V. vulnificus biotype

dc.contributor.author	Bisharat, N.
dc.contributor.author	Bialik, Anya
dc.contributor.author	Paz, E.
dc.contributor.author	Amaro González, Carmen
dc.contributor.author	Cohen, Daniel I.
dc.date.accessioned	2014-02-26T11:14:20Z
dc.date.available	2014-02-26T11:14:20Z
dc.date.issued	2011
dc.identifier.citation	Bisharat, N. Bialik, Anya Paz, E. Amaro González, Carmen Cohen, Daniel I. 2011 Serum antibodies to Vibrio vulnificus biotype 3 lipopolysaccharide and susceptibility to disease caused by the homologous V. vulnificus biotype Epidemiology and Infection 139 472 481
dc.identifier.uri	http://hdl.handle.net/10550/33346
dc.description.abstract	In 1996 an outbreak of severe soft tissue infections caused by Vibrio vulnificus unexpectedly erupted in fish consumers in Israel with relatively little morbidity in fish farmers. To test the hypothesis that recurrent exposure of fishermen to the virulent strain may have provided protection against severe or symptomatic disease, we investigated the association between the immune response to V. vulnificus biotype 3 lipopolysaccharide (BT3 LPS) and disease susceptibility in fish farmers and fish consumers. Serum samples were tested for IgA and IgG of anti-BT3 LPS in fishermen and fish consumers who suffered from V. vulnificus BT3 infections and their matched controls. Pre-existing levels of IgG (IgG0) of anti-BT3 LPS were significantly lower in diseased fishermen who developed disease associated with the homologous biotype, compared to controls. In multivariate analysis, levels of IgG0 anti-BT3 LPS remained the only variable significantly associated with disease occurrence in fishermen. Higher levels of pre-existing IgG anti-BT 3 LPS antibodies may be associated with protection against severe or symptomatic disease with the homologous biotype in fishermen but not in subjects from the general public.
dc.relation.ispartof	Epidemiology and Infection, 2011, vol. 139, p. 472-481
dc.subject	Microbiologia
dc.title	Serum antibodies to Vibrio vulnificus biotype 3 lipopolysaccharide and susceptibility to disease caused by the homologous V. vulnificus biotype
dc.type	journal article	es_ES
dc.date.updated	2014-02-26T11:14:20Z
dc.identifier.doi	10.1017/S0950268810001202
dc.identifier.idgrec	087330
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1017/S0950268810001202