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BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin Α3Β1

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BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin Α3Β1

dc.contributor.author	Wood, Elaine
dc.contributor.author	Tamborero Capilla, Silvia
dc.contributor.author	Mingarro Muñoz, Ismael
dc.contributor.author	Esteve Gassent, María Dolores
dc.date.accessioned	2014-03-26T12:11:13Z
dc.date.available	2014-03-26T12:11:13Z
dc.date.issued	2013
dc.identifier.citation	Wood, Elaine Tamborero Capilla, Silvia Mingarro Muñoz, Ismael Esteve Gassent, María Dolores (2013) BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin Α3Β1 Journal of Bacteriology 195 15 3320 3330
dc.identifier.uri	http://hdl.handle.net/10550/33695
dc.description.abstract	Lyme disease is a multisystemic disorder caused by Borrelia burgdorferi infection. Upon infection, some B. burgdorferi genes are upregulated, including members of the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) protein family, which facilitate B. burgdorferi adherence to extracellular matrix components of the host. Comparative genome analysis has revealed a new family of B. burgdorferi proteins containing the von Willebrand factor A (vWFA) domain. In the present study, we characterized the expression and membrane association of the vWFA domain-containing protein BB0172 by using in vitro transcription/translation systems in the presence of microsomal membranes and with detergent phase separation assays. Our results showed evidence of BB0172 localization in the outer membrane, the orientation of the vWFA domain to the extracellular environment, and its function as a metal ion-dependent integrin-binding protein. This is the first report of a borrelial adhesin with a metal ion-dependent adhesion site (MIDAS) motif that is similar to those observed in eukaryotic integrins and has a similar function.
dc.relation.ispartof	Journal of Bacteriology, 2013, vol. 195, num. 15, p. 3320-3330
dc.subject	Proteïnes de membrana
dc.subject	Biotecnologia
dc.title	BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin Α3Β1
dc.type	journal article	es_ES
dc.date.updated	2014-03-26T12:11:13Z
dc.identifier.doi	10.1128/JB.00187-13
dc.identifier.idgrec	094178
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1128/JB.00187-13