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Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing

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Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing

dc.contributor.author	Bañó Polo, Manuel
dc.contributor.author	Baeza Delgado, Carlos
dc.contributor.author	Orzáez Calatayud, María del Mar
dc.contributor.author	Martí Renom, Marc A.
dc.contributor.author	Abad Mazario, Concepción
dc.contributor.author	Mingarro Muñoz, Ismael
dc.date.accessioned	2014-03-26T12:40:20Z
dc.date.available	2014-03-26T12:40:20Z
dc.date.issued	2012
dc.identifier.citation	Bañó Polo, Manuel Baeza Delgado, Carlos Orzáez Calatayud, María del Mar Marti Renom, Marc Abad Mazario, Concepción Mingarro Muñoz, Ismael 2012 Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing Plos One 7 9 e44263
dc.identifier.uri	http://hdl.handle.net/10550/33702
dc.description.abstract	The vast majority of membrane proteins are anchored to biological membranes through hydrophobic α-helices. Sequence analysis of high-resolution membrane protein structures show that ionizable amino acid residues are present in transmembrane (TM) helices, often with a functional and/or structural role. Here, using as scaffold the hydrophobic TM domain of the model membrane protein glycophorin A (GpA), we address the consequences of replacing specific residues by ionizable amino acids on TM helix insertion and packing, both in detergent micelles and in biological membranes. Our findings demonstrate that ionizable residues are stably inserted in hydrophobic environments, and tolerated in the dimerization process when oriented toward the lipid face, emphasizing the complexity of protein-lipid interactions in biological membranes.
dc.relation.ispartof	Plos One, 2012, vol. 7, num. 9, p. e44263
dc.subject	Membranes (Biologia)
dc.subject	Biotecnologia
dc.title	Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing
dc.type	journal article	es_ES
dc.date.updated	2014-03-26T12:40:21Z
dc.identifier.doi	10.1371/journal.pone.0044263
dc.identifier.idgrec	079791
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1371/journal.pone.0044263