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Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria

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Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria

dc.contributor.author	Oliveira, Lidiane da Costa	es
dc.contributor.author	Giovanini, Allan Fernando	es
dc.contributor.author	Abuabara, Allan	es
dc.contributor.author	Klug, Luiz Gustavo	es
dc.contributor.author	Gonzaga, Carla Castiglia	es
dc.contributor.author	Zielak, João Cézar	es
dc.contributor.author	Urban, Cícero de Andrade	es
dc.contributor.author	Deliberador, Tatiana Miranda	es
dc.date.accessioned	2014-05-29T07:05:55Z
dc.date.available	2014-05-29T07:05:55Z
dc.date.issued	2013	es
dc.identifier.citation	Oliveira, Lidiane da Costa ; Giovanini, Allan Fernando ; Abuabara, Allan ; Klug, Luiz Gustavo ; Gonzaga, Carla Castiglia ; Zielak, João Cézar ; Urban, Cícero de Andrade ; Deliberador, Tatiana Miranda. Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 3: 510-515	es
dc.identifier.uri	http://hdl.handle.net/10550/35632
dc.description.abstract	Objective The adipose tissue represents an important reservoir of stem cells. There are few studies in the literature with which to histologically evaluate whether or not the adipose tissue graft is really a safe option to achieve bone repair. This study histologically analyzed the effect of fragmented autogenous adipose tissue grafts on bone healing in surgically created, critical-size defects (CSD) in a rabbit's calvaria. Study design Forty-two New Zealand rabbits were used in this study. CSD that were 15 mm in diameter were created in the calvarium of each animal. The defects were randomly divided into two groups: in Group C (control), the defect was filled only by a blood clot and, in Group FAT (i.e., fragmented adipose tissue), the defect was filled with fragmented autogenous adipose tissue grafts. The groups were divided into subgroups (n = 7) for euthanasia at 7, 15, and 40 days after the procedure had been conducted. Histologic and histometric analyses were performed. Data were statistically analysed with ANOVA and Tukey's tests (p < 0.05). Results The amount of bone formation did not show statistically significant differences seven days after the operation, which indicates that the groups had similar amounts of mineral deposition in the earlier period of the repair. Conversely, a significant of amount of bone matrix deposition was identified in the FAT group at 15 and 40 days following the operation, both on the border and in the body of the defect. Such an outcome was not found in the control group. Conclusion In this study, an autologous adipose tissue graft may be considered as likely biomaterial for bone regeneration, since it positively affected the amount of bone formation in surgically created CSD in the rabbits' calvaria 40 days after the procedure had been performed. Further investigations with a longer time evaluation are warranted to determine the effectiveness of autologous adipose tissue graft in the bone healing.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES