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Expression of hormonal receptors in osteosarcomas of the jaw bones: clinico-pathological analysis of 21 cases

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Expression of hormonal receptors in osteosarcomas of the jaw bones: clinico-pathological analysis of 21 cases

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dc.contributor.author Domínguez Malagón, Hugo es
dc.contributor.author González Conde, Esther es
dc.contributor.author Cano-Valdez, Ana María es
dc.contributor.author Luna Ortiz, Kuauhyama es
dc.contributor.author Mosqueda Taylor, Adalberto es
dc.date.accessioned 2014-07-04T07:53:33Z
dc.date.available 2014-07-04T07:53:33Z
dc.date.issued 2014 es
dc.identifier.citation Domínguez Malagón, Hugo ; González Conde, Esther ; Cano-Valdez, Ana María ; Luna Ortiz, Kuauhyama ; Mosqueda Taylor, Adalberto. Expression of hormonal receptors in osteosarcomas of the jaw bones: clinico-pathological analysis of 21 cases. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 1: 44-48 es
dc.identifier.uri http://hdl.handle.net/10550/36857
dc.description.abstract Background: Sexual hormones have an important role in many hormone-dependant tumors like breast and prostate carcinomas, and also a relationship has been found with bone metabolism and bone tumors. Some studies have demonstrated that the expression of hormonal receptors (HR) in osteosarcomas (OS) of long bones is associated with gender, histological grade, histological type, and possibly may be connection with pathogenesis and evolution. However, to our knowledge there are no studies of HR in osteosarcomas of craniofacial bones (OS-CF). Objectives: To assess the expression of hormonal receptors in OS-CF. Material and Methods: Twenty one cases of OS-CF were included in this study. Clinical outcome was obtained from clinical charts. Histological sections were reviewed, and immunohistochemistry studies for estrogen, progesterone and androgen receptors were performed. Results: A striking female predominance was found (2:1), with a median age of 35 years. The predominant type of OS was osteoblastic (52.4%), and histological grade was high in 86%. Follow-up was obtained in 13 cases and ranged from 6 to 118 months (median 29 months). There were 8 patients (61.5%) dead or alive with progressive disease in the last follow up. Negative expression of HR was found in 19/21 cases; one showed weak nuclear expression for estrogen receptor, and another for androgen receptor. Progesterone receptor was negative in all cases. Conclusions: OS-CF mostly affected females, most of them were of the osteoblastic type and of high grade. Hormonal expression was practically negative in osteosarcoma of craniofacial bones. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Expression of hormonal receptors in osteosarcomas of the jaw bones: clinico-pathological analysis of 21 cases es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/pubmed/medoralv19_i1_p44.pdf es

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