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Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma

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Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma

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dc.contributor.author Morelatto, Rosana es
dc.contributor.author Itoiz, María-Elina es
dc.contributor.author Guiñazú, Natalia es
dc.contributor.author Piccini, Daniel es
dc.contributor.author Gea, Susana es
dc.contributor.author López de Blanc, Silvia Adriana es
dc.date.accessioned 2014-07-04T07:55:25Z
dc.date.available 2014-07-04T07:55:25Z
dc.date.issued 2014 es
dc.identifier.citation Morelatto, Rosana ; Itoiz, María-Elina ; Guiñazú, Natalia ; Piccini, Daniel ; Gea, Susana ; López de Blanc, Silvia Adriana. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 3: 242-247 es
dc.identifier.uri http://hdl.handle.net/10550/36878
dc.description.abstract The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcino - mas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were ana - lyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by im - munohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative ( p =0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/pubmed/medoralv19_i3_p242.pdf es

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