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Association of -1082 interleukin-10 gene polymorphism in Peruvian adults with chronic periodontitis

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Association of -1082 interleukin-10 gene polymorphism in Peruvian adults with chronic periodontitis

dc.contributor.author	Chambrone, Leandro	es
dc.contributor.author	Ascarza, Amilcar	es
dc.contributor.author	Guerrero, Maria Eugenia	es
dc.contributor.author	Pannuti, Claudio	es
dc.contributor.author	Rosa, Manuel de la	es
dc.contributor.author	Salinas Prieto, Elmer	es
dc.contributor.author	Mendoza, Gerardo	es
dc.date.accessioned	2015-01-08T12:36:15Z
dc.date.available	2015-01-08T12:36:15Z
dc.date.issued	2014	es
dc.identifier.citation	Chambrone, Leandro ; Ascarza, Amilcar ; Guerrero, Maria Eugenia ; Pannuti, Claudio ; Rosa, Manuel de la ; Salinas Prieto, Elmer ; Mendoza, Gerardo. Association of -1082 interleukin-10 gene polymorphism in Peruvian adults with chronic periodontitis. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 6: 569-573	es
dc.identifier.uri	http://hdl.handle.net/10550/41167
dc.description.abstract	Objectives: The aim of this study was to assess association of the -1082 IL-10 gene polymorphism with chronic periodontitis CP in a Peruvian population. Study Design: Samples of venous blood and DNA were obtained from 106 Peruvian subjects: a) 53 periodontally healthy; and b) 53 with CP. The association of the -1082 IL-10 promoter sequences was assessed by Polymerase chain reaction-restriction fragment length polymorfism (PCR-RFLP). Student's t test were used to assess the clinical parameters, as well as the x2 test and the odds ratio (OR), with 95% confidence intervals (CI) used performed for estimates regarding genotype and allele frequencies. Results: There were statistically significant differences between groups regarding the mean bleeding on probing, mean attachment level and mean probing depth (p < 0.00001) indicating that the matching based on the evaluated groups was adequate. The x2 test found a statistically significant imbalance of genotypes between groups (p = 0.0172). The prevalence of CP was significantly higher in subjects harboring at least one A allele at position -1082 (AA and GA genotypes) in comparison to patients with the GG genotype (OR = 2.96; CI: 0.52; 5.41; p = 0.0099). Equally, subjects with the AA genotype were significantly associated to a diagnosis of CP (OR = 2.71; CI: 0.38; 5.04; p = 0.0231). On the other hand, subjects presenting a healthy periodontal status presented at least one G allele in comparison with the AA genotype (OR = 0.37; CI: 0.05, 0.69; p = 0.0231). For subjects with the GG genotype, the same positive association was observed (OR = 0.34; CI: 0.06, 0.62; p = 0.0099). There were no significant differences between groups amongst subjects with the GA genotype (OR = 1.19; CI: 0.22, 2.16; p = 0.6774). Conclusions: Within the limits of this study, IL-10 gene polymorphism at position -1082 does not appear to be associated to CP. Conversely, subjects with AA genotype seem to be at an increased risk of developing CP.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Association of -1082 interleukin-10 gene polymorphism in Peruvian adults with chronic periodontitis	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://www.medicinaoral.com/pubmed/medoralv19_i6_p569.pdf	es