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The clinical significance of CDK1 expression in oral squamous cell carcinoma

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The clinical significance of CDK1 expression in oral squamous cell carcinoma

dc.contributor.author	Chen, Xin	es
dc.contributor.author	Zhang, Feng-He	es
dc.contributor.author	Chen, Qiao-Er	es
dc.contributor.author	Wang, Yuan-Yin	es
dc.contributor.author	Wang, Yin-Long	es
dc.contributor.author	He, Ia-cai	es
dc.contributor.author	Zhou, Jian	es
dc.date.accessioned	2015-05-08T10:40:52Z
dc.date.available	2015-05-08T10:40:52Z
dc.date.issued	2015	es
dc.identifier.citation	Chen, Xin ; Zhang, Feng-He ; Chen, Qiao-Er ; Wang, Yuan-Yin ; Wang, Yin-Long ; He, Ia-cai ; Zhou, Jian. The clinical significance of CDK1 expression in oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 1: 4-	es
dc.identifier.uri	http://hdl.handle.net/10550/43617
dc.description.abstract	Objectives: To evaluate the clinical significance of cyclin-dependent kinase 1 (CDK 1 ) in 77 oral squamous cell carcinomas (OSCC) using immunohistochemical methods. Study Design: Immunohistochemical expression of CDK 1 was compared with various clinicopathological features in 77 OSCC and 60 controlled epithelia adjacent to the tumours. In addition, correlation of CDK 1 expression and prognostic and the 5-year accumulative survival rate of OSCC were investigated. Results: The CDK 1 protein was expressed in 52 cases of 77 tumor tissues (67.5%), compared with 21 cases of 60 controlled (35.0%). The expression of CDK 1 was significantly correlated with the histological grade of OSCC ( P <0.05). The CDK 1 protein was over-expressed in recurrent tumors or in those with lymph node metastasis. Statistical analysis showed a significant reduction in the 5-year accumulative survival rate in CDK 1 positive cases compared with CDK 1 negative cases ( P <0.05). Namely, the CDK 1 positive patients had poor prognosis. Conclusions: The expression of CDK 1 might serve as malignant degree and prognostic markers for the survival of OSCC	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	The clinical significance of CDK1 expression in oral squamous cell carcinoma	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://www.medicinaoral.com/pubmed/medoralv20_i1_p4.pdf	es