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Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells

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Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells

dc.contributor.author	Kim, Jisun	es
dc.contributor.author	Kim, Sangwoo	es
dc.contributor.author	Jeon, Sangmi	es
dc.contributor.author	Hui, Zheng	es
dc.contributor.author	Kim, Young	es
dc.contributor.author	Im, Yeonggwan	es
dc.contributor.author	Lim, Wonbong	es
dc.contributor.author	Kim, Changsu	es
dc.contributor.author	Choi, Hongran	es
dc.contributor.author	Kim, Okjoon	es
dc.date.accessioned	2015-05-27T11:47:59Z
dc.date.available	2015-05-27T11:47:59Z
dc.date.issued	2015	es
dc.identifier.citation	Kim, Jisun ; Kim, Sangwoo ; Jeon, Sangmi ; Hui, Zheng ; Kim, Young ; Im, Yeonggwan ; Lim, Wonbong ; Kim, Changsu ; Choi, Hongran ; Kim, Okjoon. Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 2: 11-	es
dc.identifier.uri	http://hdl.handle.net/10550/44062
dc.description.abstract	Objectives: Abnormal cellular immune response has been considered to be responsible for oral lesions in recurrent aphthous stomatitis. Zinc has been known to be an essential nutrient metal that is necessary for a broad range of biological activities including antioxidant, immune mediator, and anti-inflammatory drugs in oral mucosal disease. The objective of this study was to investigate the effects of zinc in a phorbol-12-myristate-13-acetate (PMA)- treated inflammatory model on human gingival fibroblast cells (hGFs). Study Design: Cells were pre-treated with zinc chloride, followed by PMA in hGFs. The effects were assessed on cell viability, cyclooxygenease-1,2(COX-1/2) protein expression, PGE 2 release, ROS production and cytokine release, Results: The effects were assessed on cell viability, COX1/2 protein expression, PGE 2 release, ROS production, cytokine release. The results showed that, in the presence of PMA, zinc treatment leads to reduce the production of ROS, which results in decrease of COX-2 expression and PGE 2 release. Conclusions: Thus, we suggest that zinc treatment leads to the mitigation of oral inflammation and may prove to be an alternative treatment for recurrent aphthous stomatitis.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5081408&orden=0	es