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Metabolic Networks of Sodalis glossinidius: A Systems Biology Approach to Reductive Evolution

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Metabolic Networks of Sodalis glossinidius: A Systems Biology Approach to Reductive Evolution

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dc.contributor.author Belda, Eugeni es_ES
dc.contributor.author Silva Moreno, Francisco J. es_ES
dc.contributor.author Peretó, Juli es_ES
dc.contributor.author Moya, Andrés es_ES
dc.date.accessioned 2015-06-19T10:17:57Z
dc.date.available 2015-06-19T10:17:57Z
dc.date.issued 2012 es_ES
dc.identifier.citation PLoS ONE Vol. 7 Issue 1: es_ES
dc.identifier.uri http://hdl.handle.net/10550/44529
dc.description.abstract BackgroundGenome reduction is a common evolutionary process affecting bacterial lineages that establish symbiotic or pathogenic associations with eukaryotic hosts. Such associations yield highly reduced genomes with greatly streamlined metabolic abilities shaped by the type of ecological association with the host. Sodalis glossinidius, the secondary endosymbiont of tsetse flies, represents one of the few complete genomes available of a bacterium at the initial stages of this process. In the present study, genome reduction is studied from a systems biology perspective through the reconstruction and functional analysis of genome-scale metabolic networks of S. glossinidius.ResultsThe functional profile of ancestral and extant metabolic networks sheds light on the evolutionary events underlying transition to a host-dependent lifestyle. Meanwhile, reductive evolution simulations on the extant metabolic network can predict possible future evolution of S. glossinidius in the context of genome reduction. Finally, knockout simulations in different metabolic systems reveal a gradual decrease in network robustness to different mutational events for bacterial endosymbionts at different stages of the symbiotic association.ConclusionsStoichiometric analysis reveals few gene inactivation events whose effects on the functionality of S. glossinidius metabolic systems are drastic enough to account for the ecological transition from a free-living to host-dependent lifestyle. The decrease in network robustness across different metabolic systems may be associated with the progressive integration in the more stable environment provided by the insect host. Finally, reductive evolution simulations reveal the strong influence that external conditions exert on the evolvability of metabolic systems. es_ES
dc.title Metabolic Networks of Sodalis glossinidius: A Systems Biology Approach to Reductive Evolution es_ES
dc.type journal article es_ES
dc.identifier.doi 10.1371/journal.pone.0030652 es_ES
dc.identifier.idgrec 073399 es_ES

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