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Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS

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Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS

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dc.contributor.author Bribián, Ana es_ES
dc.contributor.author Fontana, Xavier es_ES
dc.contributor.author Llorens, Franc es_ES
dc.contributor.author Gavín, Rosalina es_ES
dc.contributor.author Reina, Manuel es_ES
dc.contributor.author García Verdugo, José Manuel es_ES
dc.contributor.author Torres, Juan María es_ES
dc.contributor.author Castro, Fernando de es_ES
dc.contributor.author Río, José Antonio del es_ES
dc.date.accessioned 2015-06-19T10:17:59Z
dc.date.available 2015-06-19T10:17:59Z
dc.date.issued 2012 es_ES
dc.identifier.citation PLoS ONE Vol. 7 Issue 4: es_ES
dc.identifier.uri http://hdl.handle.net/10550/44537
dc.description.abstract There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrPc) to this process remains unclear. PrPc is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein involved in diverse cellular processes during the development and maturation of the mammalian central nervous system (CNS). Here we describe how PrPc influences oligodendrocyte proliferation in the developing and adult CNS. OPCs that lack PrPc proliferate more vigorously at the expense of a delay in differentiation, which correlates with changes in the expression of oligodendrocyte lineage markers. In addition, numerous NG2-positive cells were observed in cortical regions of adult PrPc knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells. es_ES
dc.title Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS es_ES
dc.type journal article es_ES
dc.identifier.doi 10.1371/journal.pone.0033872 es_ES
dc.identifier.idgrec 076904 es_ES

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