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Common Variants of the Liver Fatty Acid Binding Protein Gene Influence the Risk of Type 2 Diabetes and Insulin Resistance in Spanish Population

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Common Variants of the Liver Fatty Acid Binding Protein Gene Influence the Risk of Type 2 Diabetes and Insulin Resistance in Spanish Population

dc.contributor.author	Mansego Talavera, Mª Luisa	es_ES
dc.contributor.author	Martínez, Fernando	es_ES
dc.contributor.author	Martínez-Larrad, Maria Teresa	es_ES
dc.contributor.author	Zabena, Carina	es_ES
dc.contributor.author	Rojo, Gemma	es_ES
dc.contributor.author	Morcillo, Sonsoles	es_ES
dc.contributor.author	Soriguer, Federico	es_ES
dc.contributor.author	Martín Escudero, Juan Carlos	es_ES
dc.contributor.author	Serrano-Ríos, Manuel	es_ES
dc.contributor.author	Redón i Más, Josep	es_ES
dc.contributor.author	Chaves Martínez, Felipe Javier	es_ES
dc.date.accessioned	2015-06-19T10:19:53Z
dc.date.available	2015-06-19T10:19:53Z
dc.date.issued	2012	es_ES
dc.identifier.citation	PLoS ONE Vol. 7 Issue 3:	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44555
dc.description.abstract	SummaryThe main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated.Methods1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in both studies. Fifteen SNPs previously associated with metabolic traits or with potential influence in the gene expression within the FABP1-4 genes were genotyped with SNPlex and tested. Age, sex and BMI were used as covariates in the logistic regression model.ResultsOne polymorphism (rs2197076) and two haplotypes of the FABP-1 showed a strong association with the risk of DM2 in the original population. This association was further confirmed in the second population as well as in the pooled sample. None of the other analyzed variants in FABP2, FABP3 and FABP4 genes were associated. There was not a formal interaction between rs2197076 and fat intake. A significant association between the rs2197076 and the haplotypes of the FABP1 and HOMA-IR was also present in the replication population.ConclusionsThe study supports the role of common variants of the FABP-1 gene in the development of type 2 diabetes in Caucasians.	es_ES
dc.title	Common Variants of the Liver Fatty Acid Binding Protein Gene Influence the Risk of Type 2 Diabetes and Insulin Resistance in Spanish Population	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1371/journal.pone.0031853	es_ES
dc.identifier.idgrec	084691	es_ES