NAGIOS: RODERIC FUNCIONANDO

Global and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive features

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Global and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive features

dc.contributor.author	Crespo Facorro, Benedicto	es_ES
dc.contributor.author	Roiz-Santiáñez, R.	es_ES
dc.contributor.author	Pérez-Iglesias, R.	es_ES
dc.contributor.author	Rodriguez-Sanchez, J. M.	es_ES
dc.contributor.author	Mata, I.	es_ES
dc.contributor.author	Tordesillas-Gutierrez, D.	es_ES
dc.contributor.author	Sanchez, E.	es_ES
dc.contributor.author	Tabarés Seisdedos, Rafael	es_ES
dc.contributor.author	Andreasen, N.	es_ES
dc.contributor.author	Magnotta, V.	es_ES
dc.contributor.author	Vázquez-Barquero, J.L.	es_ES
dc.date.accessioned	2015-06-22T09:51:18Z
dc.date.available	2015-06-22T09:51:18Z
dc.date.issued	2010	es_ES
dc.date.issued	2011	es_ES
dc.identifier.citation	Psychological medicine Vol. 41 Issue 7: pp. 1449-1460	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44677
dc.description.abstract	BackgroundThe thickness of the cortical mantle is a sensitive measure for identifying alterations in cortical structure. We aimed to explore whether first episode schizophrenia patients already show a significant cortical thinning and whether cortical thickness anomalies may significantly influence clinical and cognitive features.MethodWe investigated regional changes in cortical thickness in a large and heterogeneous sample of schizophrenia spectrum patients (n=142) at their first break of the illness and healthy controls (n=83). Magnetic resonance imaging brain scans (1.5 T) were obtained and images were analyzed by using BRAINS2. The contribution of sociodemographic, cognitive and clinical characterictics was investigated.ResultsPatients showed a significant total cortical thinning (F=17.55, d=−0.62, p<0.001) and there was a diffuse pattern of reduced thickness (encompassing frontal, temporal and parietal cortices) (all p’s<0.001, d’s>0.53). No significant group × gender interactions were observed (all p’s>0.15). There were no significant associations between the clinical and pre-morbid variables and cortical thickness measurements (all r’s<0.12). A weak significant negative correlation between attention and total (r=−0.24, p=0.021) and parietal cortical thickness (r=−0.27, p=0.009) was found in patients (thicker cortex was associated with lower attention). Our data revealed a similar pattern of cortical thickness changes related to age in patients and controls.ConclusionsCortical thinning is independent of gender, age, age of onset and duration of the illness and does not seem to significantly influence clinical and functional symptomatology. These findings support a primary neuro-development disorder affecting the normal cerebral cortex development in schizophrenia.	es_ES
dc.subject	brain	es_ES
dc.subject	cortical thickness	es_ES
dc.subject	endophenotype	es_ES
dc.subject	MRI	es_ES
dc.subject	schizophrenia	es_ES
dc.title	Global and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive features	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1017/S003329171000200X	es_ES
dc.identifier.idgrec	076079	es_ES