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Double-blind, randomized pilot study of bioadhesive chlorhexidine gel in the prevention and treatment of mucositis induced by chemoradiotherapy of head and neck cancer

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Double-blind, randomized pilot study of bioadhesive chlorhexidine gel in the prevention and treatment of mucositis induced by chemoradiotherapy of head and neck cancer

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dc.contributor.author Díaz Sánchez, Rosa María es
dc.contributor.author Pachón Ibáñez, Jerónimo es
dc.contributor.author Marín Conde, Fátima es
dc.contributor.author Rodríguez Caballero, Ángela es
dc.contributor.author Gutiérrez Pérez, José Luis es
dc.contributor.author Torres Lagares, Daniel es
dc.date.accessioned 2015-07-06T07:21:13Z
dc.date.available 2015-07-06T07:21:13Z
dc.date.issued 2015 es
dc.identifier.citation Díaz Sánchez, Rosa María ; Pachón Ibáñez, Jerónimo ; Marín Conde, Fátima ; Rodríguez Caballero, Ángela ; Gutiérrez Pérez, José Luis ; Torres-Lagares, Daniel. Double-blind, randomized pilot study of bioadhesive chlorhexidine gel in the prevention and treatment of mucositis induced by chemoradiotherapy of head and neck cancer. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 3: 14- es
dc.identifier.uri http://hdl.handle.net/10550/45043
dc.description.abstract Background: To evaluate, in an initial way, the effectiveness of bioadhesive chlorhexidine gel 0.2% versus placebo as a preventive and therapeutic intervention of oral mucositis induced by radiation therapy and chemotherapy in patients diagnosed with head and neck cancer treated with chemoradiotherapy. Material and Methods: In this pilot study, 7 patients (range of age: 18- 65), having histological documented diagnosis of squamous carcinoma on the head and neck region in stage III and IV, and receiving combined radiation treatment and chemotherapy (cisplatin 100 mg/m2 IV on days 1, 22, and 43 of irradiation) were studied. Simultaneously, a topical application was performed with bioadhesive chlorhexidine gel 0.2% in the study group, and the placebo gel for the control group in 5 applications per day, from the time of initiation of cancer treatment to 2 weeks after completion of chemo-radiotherapy treatment (11 weeks of follow-up). The gradation of mucositis, pain, analgesic consumption, infectious complications, and treatment tolerance was measured. Results: After 7 patients completed the protocol, any differences were observed between groups in an interval analysis. Mucositis, pain, and tolerance was similar in both groups. Conclusions: Our results must be interpreted with caution due to the reduced sample size, but the use of bioadhesive chlorhexidine gel 0.2% didn’t contribute clinical improvement to the oral mucositis induced by radiation therapy and chemotherapy. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Double-blind, randomized pilot study of bioadhesive chlorhexidine gel in the prevention and treatment of mucositis induced by chemoradiotherapy of head and neck cancer es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5122591&orden=0 es

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