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Nested PCR for detection of HSV-1 in oral mucosa

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Nested PCR for detection of HSV-1 in oral mucosa

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dc.contributor.author Jalouli, Miranda-Masoumeh es
dc.contributor.author Jalouli, Jamshid es
dc.contributor.author Hasséus, Bengt es
dc.contributor.author Öhman, Jenny es
dc.contributor.author Hirsch, Jan-Michaél es
dc.contributor.author Sand, Lars es
dc.date.accessioned 2016-01-20T11:03:29Z
dc.date.available 2016-01-20T11:03:29Z
dc.date.issued 2015 es
dc.identifier.citation Jalouli, Miranda-Masoumeh ; Jalouli, Jamshid ; Hasséus, Bengt ; Öhman, Jenny ; Hirsch, Jan-Michaél ; Sand, Lars. Nested PCR for detection of HSV-1 in oral mucosa. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 6: 5- es
dc.identifier.uri http://hdl.handle.net/10550/50151
dc.description.abstract Background: It has been estimated that 15%-20% of human tumours are driven by infection and inflammation, and viral infections play an important role in malignant transformation. The evidence that herpes simplex virus type 1 (HSV-1) could be involved in the aetiology of oral cancer varies from weak to persuasive. This study aimed to investigate by nested PCR (NPCR) the prevalence of HSV-1 in samples from normal oral mucosa, oral leukoplakia, and oral squamous cell carcinoma (OSCC). Material and Methods: We investigated the prevalence of HSV-1 in biopsies obtained from 26 fresh, normal oral mucosa from healthy volunteers as well as 53 oral leukoplakia and 27 OSCC paraffin-embedded samples. DNA was extracted from the specimens and investigated for the presence of HSV-1 by nested polymerase chain reaction (NPCR) and DNA sequencing. Results: HSV-1 was detected in 14 (54%) of the healthy samples, in 19 (36%) of the oral leukoplakia samples, and in 14 (52%) of the OSCC samples. The differences were not statistically significant. Conclusions: We observed a high incidence of HSV-1 in healthy oral mucosa, oral leukoplakia, and OSCC tissues. Thus, no connection between OSCC development and presence of HSV-1 was detected. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Nested PCR for detection of HSV-1 in oral mucosa es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5277076&orden=0 es

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