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Toxicity test of a dental commercial composite in rats.

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Toxicity test of a dental commercial composite in rats.

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dc.contributor.author Ponce Bravo, Santa es
dc.contributor.author Ledesma Montes, Constantino es
dc.contributor.author Martinez-Rivera, Jorge I. es
dc.contributor.author Morales-Sanchez, Israel es
dc.date.accessioned 2016-06-24T12:15:24Z
dc.date.available 2016-06-24T12:15:24Z
dc.date.issued 2011 es
dc.identifier.citation Ponce Bravo, Santa ; Ledesma Montes, Constantino ; Martinez-Rivera, Jorge I. ; Morales-Sanchez, Israel. Toxicity test of a dental commercial composite in rats.. En: Journal of Clinical and Experimental Dentistry, 2011, Vol. 3, No. 4: 280-283 es
dc.identifier.uri http://hdl.handle.net/10550/54198
dc.description.abstract Objective: The aim of this study was to determine the 90-day subchronic toxicity of one triethylene glycol dimethacrylate containing composite (MEDENTAL Light-Cure Composite™) orally administered to rats according to OECD no. 48 guidelines and the requirements specified in the International Organization for Standardization 10993-11. Study design: The composite was administered orally to Wistar rats during 90 days and they were observed to determine changes in their behavior, eye and skin signs and other attitudes such as aggressiveness, posture, walking and response to handling. After 90 days they were sacrificed to determine blood alterations, special hematological tests were done and histopathological changes in 33 different organs were assessed. Results: Under the experimental conditions, our results showed that the composite tested in this study did not produce significant changes in clinical behavior of the animals. Microscopic review of the Hematoxilin and Eosin stained slides obtained from 33 analyzed organs showed no abnormal inflammatory or cytological changes and all hematological special tests were within normal limits. Conclusions: The results of this study show that under our experimental conditions the MEDENTAL Light-Cure Composite™ does not produce inflammatory or cytological changes suggestive of toxicity. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Toxicity test of a dental commercial composite in rats. es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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