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Brain Changes in Long-Term Zen Meditators Using Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: A Controlled Study

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Brain Changes in Long-Term Zen Meditators Using Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: A Controlled Study

dc.contributor.author	Fayed, Nicolás
dc.contributor.author	López del Hoyo, Yolanda
dc.contributor.author	Andrés, Eva
dc.contributor.author	Serrano Blanco, Antoni
dc.contributor.author	Bellon, Juan
dc.contributor.author	Aguilar, Keyla
dc.contributor.author	Cebolla i Martí, Ausiàs Josep
dc.contributor.author	García Campayo, Javier
dc.date.accessioned	2016-06-28T07:46:53Z
dc.date.available	2016-06-28T07:46:53Z
dc.date.issued	2013
dc.identifier.citation	Fayed, Nicolás; Lopez del Hoyo, Yolanda; Andrés, Eva; Serrano Blanco, Antoni; Bellon, Juan; Aguilar, Keyla; Cebolla i Martí, Ausiàs Josep García Campayo, Javier (2013) Brain Changes in Long-Term Zen Meditators Using Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: A Controlled Study Plos One 8 3 e58476
dc.identifier.uri	http://hdl.handle.net/10550/54274
dc.description.abstract	Introduction: This work aimed to determine whether 1H magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) are correlated with years of meditation and psychological variables in long-term Zen meditators compared to healthy non-meditator controls. Materials and Methods: Design. Controlled, cross-sectional study. Sample. Meditators were recruited from a Zen Buddhist monastery. The control group was recruited from hospital staff. Meditators were administered questionnaires on anxiety, depression, cognitive impairment and mindfulness. 1H-MRS (1.5 T) of the brain was carried out by exploring four areas: both thalami, both hippocampi, the posterior superior parietal lobule (PSPL) and posterior cingulate gyrus. Predefined areas of the brain were measured for diffusivity (ADC) and fractional anisotropy (FA) by MR-DTI. Results: Myo-inositol (mI) was increased in the posterior cingulate gyrus and Glutamate (Glu), N-acetyl-aspartate (NAA) and N-acetyl-aspartate/Creatine (NAA/Cr) was reduced in the left thalamus in meditators. We found a significant positive correlation between mI in the posterior cingulate and years of meditation (r = 0.518; p = .019). We also found significant negative correlations between Glu (r =20.452; p = .045), NAA (r =20.617; p = .003) and NAA/Cr (r =20.448; P = .047) in the left thalamus and years of meditation. Meditators showed a lower Apparent Diffusion Coefficient (ADC) in the left posterior parietal white matter than did controls, and the ADC was negatively correlated with years of meditation (r =20.4850, p = .0066). Conclusions: The results are consistent with the view that mI, Glu and NAA are the most important altered metabolites. This study provides evidence of subtle abnormalities in neuronal function in regions of the white matter in meditators.
dc.language.iso	eng
dc.relation.ispartof	Plos One, 2013, vol. 8, num. 3, p. e58476
dc.subject	Fisiologia humana
dc.subject	Psicologia
dc.title	Brain Changes in Long-Term Zen Meditators Using Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: A Controlled Study
dc.type	journal article	es_ES
dc.date.updated	2016-06-28T07:46:54Z
dc.identifier.doi	10.1371/journal.pone.0058476
dc.identifier.idgrec	113125
dc.rights.accessRights	open access	es_ES