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Expression of p53 Protein and Tumor Angiogenesis as Prognostic Factors in Nasopharyngeal Carcinoma Patients.

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Expression of p53 Protein and Tumor Angiogenesis as Prognostic Factors in Nasopharyngeal Carcinoma Patients.

dc.contributor.author	Rubio, L.
dc.contributor.author	Burgos, J.S.
dc.contributor.author	Lopez-Guerrero, J.A.
dc.contributor.author	Morera Pérez, Constantino
dc.contributor.author	Vera Sempere, Francisco José
dc.date.accessioned	2016-07-08T12:39:30Z
dc.date.available	2016-07-08T12:39:30Z
dc.date.issued	2002
dc.identifier.citation	Rubio, L. Burgos, J.S. Lopez-Guerrero, J.A. Morera, Constantino Vera-Sempere, Francisco José 2002 Expression of p53 Protein and Tumor Angiogenesis as Prognostic Factors in Nasopharyngeal Carcinoma Patients. Pathology Research and Practice 158 334 338
dc.identifier.uri	http://hdl.handle.net/10550/54434
dc.description.abstract	The objective of this study was to evaluate the possible prognostic significance of p53 protein overexpression and tumor angiogenesis (TA) in nasopharyngeal carcinoma (NPC) patients, together with other clinicopathological variables. Forty-two NPC patients were evaluated in relation to survival. Nuclear p53 overexpression in neoplastic and endothelial cells was detected by immunohistochemistry (IHC) with the monoclonal antibody DO-7 and the polyclonal antibody against factor VIII-related antigen, respectively. Thereafter, we evaluated p53 cases in order to determine their nuclear immunoreactivity from negative (-) to positive (+, ++, +++). In addition, microvessels were counted in the most active areas of tumor neovascularization or hotspots using an image computer analyzer (MicroImage®). A Cox multiple regression survival analysis was used to determine the best prognostic indicators in NPC patients. As a result, tumor microvessel count, considered as a continuous variable, was the most important independent prognostic indicator in relation to survival (p = 0.0273), with a relative risk of death of 2,4399 [95% confidence interval = 1.1051 ; 5.3871] associated with the highest microvessel counts. Moreover, the only clinicopathological variable that demonstrated prognostic value in a Cox multiple regression survival analysis was histological type (p = 0.05). In addition, we did not observe any statistical association between intratumoral microvessel density (IMD), clinicopathological variables and p53 protein expression. Key words: p53 protein - Angiogenesis - Morphometry - Prognosis - Nasopharyngeal carcinoma
dc.language.iso	eng
dc.relation.ispartof	Pathology Research and Practice, 2002, vol. 158, p. 334-338
dc.subject	Càncer
dc.subject	Nas Malalties
dc.subject	Patologia
dc.title	Expression of p53 Protein and Tumor Angiogenesis as Prognostic Factors in Nasopharyngeal Carcinoma Patients.
dc.type	journal article	es_ES
dc.date.updated	2016-07-08T12:39:30Z
dc.identifier.doi	10.1078/0344-0338-00193
dc.identifier.idgrec	036215
dc.rights.accessRights	open access	es_ES