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Novel host-specific iron acquisition system in the zoonotic pathogen Vibrio vulnificus

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Novel host-specific iron acquisition system in the zoonotic pathogen Vibrio vulnificus

dc.contributor.author	Pajuelo Gámez, David
dc.contributor.author	Lee, Chung-Te
dc.contributor.author	Roig Molina, Francisco José
dc.contributor.author	Hor, Lien-I.
dc.contributor.author	Amaro González, Carmen
dc.date.accessioned	2016-07-11T14:18:25Z
dc.date.available	2016-07-11T14:18:25Z
dc.date.issued	2015
dc.identifier.citation	Pajuelo Gámez, David Lee, Chung-Te Roig Molina, Francisco José Hor, Lien-I. Amaro González, Carmen 2015 Novel host-specific iron acquisition system in the zoonotic pathogen Vibrio vulnificus Environmental Microbiology
dc.identifier.uri	http://hdl.handle.net/10550/54442
dc.description.abstract	Vibrio vulniﬁcus is a marine bacterium associated with human and ﬁsh (mainly farmed eels) diseases globally known as vibriosis. The ability to infect and overcome eel innate immunity relies on a virulence plasmid (pVvbt2) speciﬁc for biotype 2 (Bt2) strains. In the present study, we demonstrated that pVvbt2 encodes a host-speciﬁc iron acquisition system that depends on an outer membrane receptor for eel transferrin called Vep20. The inactivation of vep20 did not affect either bacterial growth in human plasma or virulence for mice, while bacterial growth in eel blood/plasma was abolished and virulence for eels was sig-niﬁcantly impaired. Furthermore, vep20 is an iron-regulated gene overexpressed in eel blood during artiﬁcially induced vibriosis both in vitro and in vivo. Interestingly, homologues to vep20 were identiﬁed in the transferable plasmids of two ﬁsh pathogen species of broad-host range, Vibrio harveyi (pVh1) and Photobacterium damselae subsp. damselae (pPHDD1). These data suggest that Vep20 belongs to a new family of plasmid-encoded ﬁsh-speciﬁc transferrin receptors, and the acquisition of these plasmids through horizontal gene transfer is likely positively selected in the ﬁsh-farming environ-ment. Moreover, we propose Ftbp (ﬁsh transferrin binding proteins) as a formal name for this family of proteins.
dc.language.iso	eng
dc.relation.ispartof	Environmental Microbiology, 2015
dc.subject	Bacteris patògens
dc.subject	Microbiologia
dc.title	Novel host-specific iron acquisition system in the zoonotic pathogen Vibrio vulnificus
dc.type	journal article	es_ES
dc.date.updated	2016-07-11T14:18:26Z
dc.identifier.doi	10.1111/1462-2920.12782
dc.identifier.idgrec	101783
dc.rights.accessRights	open access	es_ES