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Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium

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Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium

dc.contributor.author	Aldasoro Celaya, Martín
dc.contributor.author	Jorda, Adrian
dc.contributor.author	Aldasoro, Constanza
dc.contributor.author	Marchio, Patricia
dc.contributor.author	Guerra Ojeda, Sol
dc.contributor.author	Gimeno Raga, Marc
dc.contributor.author	Mauricio Aviñó, María Dolores
dc.contributor.author	Iradi Casal, Antonio
dc.contributor.author	Obrador, Elena
dc.contributor.author	Vila Salinas, José María
dc.contributor.author	Vallés Martí, Lilián Soraya
dc.date.accessioned	2017-05-02T11:19:12Z
dc.date.available	2017-05-02T11:19:12Z
dc.date.issued	2017
dc.identifier.citation	Aldasoro Celaya, Martín Jorda, Adrian Aldasoro, Constanza Marchio, Patricia Guerra Ojeda, Sol Gimeno Raga, Marc Mauricio Aviñó, María Dolores Iradi Casal, Antonio Obrador, Elena Vila Salinas, José María Vallés Martí, Lilián Soraya 2017 Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium. International Journal Of Medical Sciences 23 14(3) 224 230
dc.identifier.uri	http://hdl.handle.net/10550/58338
dc.description.abstract	Rocuronium (ROC) and Vecuronium (VEC) are the most currently used steroidal non-depolarizing neuromuscular blocking (MNB) agents. Sugammadex (SUG) rapidly reverses steroidal NMB agents after anaesthesia. The present study was conducted in order to evaluate neuronal effects of SUG alone and in combination with both ROC and VEC. Using MTT, CASP-3 activity and Western-blot we determined the toxicity of SUG, ROC or VEC in neurons in primary culture. SUG induces apoptosis/necrosis in neurons in primary culture and increases cytochrome C (CytC), apoptosis-inducing factor (AIF), Smac/Diablo and Caspase 3 (CASP-3) protein expression. Our results also demonstrated that both ROC and VEC prevent these SUG effects. The protective role of both ROC and VEC could be explained by the fact that SUG encapsulates NMB drugs. In BBB impaired conditions it would be desirable to control SUG doses to prevent the excess of free SUG in plasma that may induce neuronal damage. A balance between SUG, ROC or VEC would be necessary to prevent the risk of cell damage
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Medical Sciences, 2017, vol. 23, num. 14(3), p. 224-230
dc.subject	estrès oxidatiu
dc.subject	neurones
dc.title	Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium
dc.type	journal article	es_ES
dc.date.updated	2017-05-02T11:19:12Z
dc.identifier.doi	10.7150/ijms.17545.eCollection2017
dc.identifier.idgrec	116955
dc.rights.accessRights	open access	es_ES