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Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis : evidence from a meta-analysis with new published findings

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Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis : evidence from a meta-analysis with new published findings

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dc.contributor.author da Silva, Felipe Rodolfo Pereira es
dc.contributor.author Cardoso Guimarães Vasconcelos, Any Carolina es
dc.contributor.author de Carvalho França, Luiz Felipe es
dc.contributor.author di Lenardo, David es
dc.contributor.author Rodrigues, Luana Silva es
dc.contributor.author Barreto do Nascimento, Maria Luísa Lima es
dc.contributor.author Vasconcelos, Daniel Fernando Pereira es
dc.date.accessioned 2017-07-21T11:50:41Z
dc.date.available 2017-07-21T11:50:41Z
dc.date.issued 2017 es
dc.identifier.citation da Silva, Felipe Rodolfo Pereira ; Cardoso Guimarães Vasconcelos, Any Carolina ; de Carvalho França, Luiz Felipe ; di Lenardo, David ; Rodrigues, Luana Silva ; Barreto do Nascimento, Maria Luísa Lima ; Vasconcelos, Daniel Fernando Pereira . Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis : evidence from a meta-analysis with new published findings. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 1 2017: 15- es
dc.identifier.uri http://hdl.handle.net/10550/59805
dc.description.abstract Periodontitis results from an inflammatory response caused by accumulative microorganisms in periodontal sites. Several factors are involved in pathogenesis of periodontitis, for example the -889 C/T polymorphism in interleukin-1A gene. This study aimed to evaluate the relationship between this polymorphism and risk of development of chronic periodontitis by a meta-analysis based in new published findings. Thereunto a review in literature was performed in the electronic biomedical and education databases (Cochrane Library, Google Scholar, MEDLINE and PubMed) to studies published before August 2, 2015, the abstracts were evaluated and the data extraction performed by two calibrated examiners. The calculations of the meta-analysis were obtained through statistical software Review Manager version 5.2 with calculation of Odds Ratio (OR), heterogeneity (I²) and Funnel plots with P <0.05. In overall, twenty-one case/control studies were selected with 2,174 patients with chronic periodontitis and 1, 756 controls. The meta-analysis showed T allele was associated with chronic periodontitis (OR = 1.22, 95% CI: 1.09, 1.36, P = 0.0004) with decreased value to heterogeneity (I² = 15%, P = 0.28). TT genotype was associated to patients with chronic periodontitis (OR = 1.40, 95% CI: 1.07, 1.83, P = 0.01). No publication bias was found in this meta-analysis by asymmetry in Funnel plots. This meta-analysis with 2,174 patients with chronic periodontitis and 1, 756 controls evidenced the -889 C/T polymorphism is associated to risk of development of chronic periodontitis with no significant value to heterogeneity to allelic evaluation. es
dc.title Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis : evidence from a meta-analysis with new published findings es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21233 es
dc.type.hasVersion VoR es_ES

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