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Evidence for transforming growth factor-beta 3 gene polymorphism in non-syndromic cleft lip and palate patients from indian sub-continent

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Evidence for transforming growth factor-beta 3 gene polymorphism in non-syndromic cleft lip and palate patients from indian sub-continent

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dc.contributor.author Shaikh, Saleem es
dc.contributor.author Ravenndranath, Rajendran es
dc.contributor.author Banerjee, Moinak es
dc.contributor.author Joseph, Anna es
dc.contributor.author Jahgirdar, Pramod es
dc.date.accessioned 2017-07-25T12:12:29Z
dc.date.available 2017-07-25T12:12:29Z
dc.date.issued 2012 es
dc.identifier.citation Shaikh, Saleem ; Ravenndranath, Rajendran ; Banerjee, Moinak ; Joseph, Anna ; Jahgirdar, Pramod. Evidence for transforming growth factor-beta 3 gene polymorphism in non-syndromic cleft lip and palate patients from indian sub-continent. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 2 2012: 14- es
dc.identifier.uri http://hdl.handle.net/10550/60000
dc.description.abstract Objectives: Orofacial clefts are major human birth defects with complex etiology. Previous studies have proposed Transforming growth factor - beta 3 (TGF-?3) gene as a key player in contributing to non-syndromic cleft lip and palate, however none of the studies have yet included Indian population. Hence this study was designed to detect TGF-?3 gene polymorphism in nonsyndromic cleft lip and palate patients from Indian population which is genetically distinct from previously studied populations. Study Design: Peripheral blood samples of forty non-syndromic cleft lip and palate patients and forty unaffected individuals were collected for a case - control study design. Ethical clearance from the institutional review board and informed consent from all subjects was obtained. DNA extracted from the cases and controls was amplified using polymerase chain reaction (PCR) with TGF-?3 specific primers. The obtained fragments were sequenced and TGF-?3 gene polymorphisms were assessed based on the number of CA repeats. Results: Chi -square test was used to compare the case and control groups. Results showed a significant difference in the number of CA repeats between the case and the control groups (p=0.01). Conclusion: This study confirms the crucial role of TGF-?3 in the fusion of palatal shelves during development and further, provides novel evidence of TGF-?3 gene polymorphism in the etiology of nonsyndromic cleft lip and palate in Indian subpopulation. © Medicina Oral S. L. es
dc.title Evidence for transforming growth factor-beta 3 gene polymorphism in non-syndromic cleft lip and palate patients from indian sub-continent es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17453 es
dc.type.hasVersion VoR es_ES

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