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Study of total stimulated saliva flow and hyperpigmentation in the oral mucosa of patients diagnosed with hereditary hemochromatosis. Series of 25 cases

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Study of total stimulated saliva flow and hyperpigmentation in the oral mucosa of patients diagnosed with hereditary hemochromatosis. Series of 25 cases

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dc.contributor.author Sánchez Pablo, Miguel Angel es
dc.contributor.author González García, Vanesa es
dc.contributor.author del Castillo Rueda, Alejandro es
dc.date.accessioned 2017-07-26T06:39:13Z
dc.date.available 2017-07-26T06:39:13Z
dc.date.issued 2012 es
dc.identifier.citation Sánchez Pablo, Miguel Angel ; González García, Vanesa ; del Castillo Rueda, Alejandro. Study of total stimulated saliva flow and hyperpigmentation in the oral mucosa of patients diagnosed with hereditary hemochromatosis. Series of 25 cases. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 1 2012: 17- es
dc.identifier.uri http://hdl.handle.net/10550/60005
dc.description.abstract Objective: To study lesions in the oral cavity of patients with hereditary hemochromatosis and determine their association with iron overload. Study Design: We took a clinical history, examined the pigmentation of the oral mucosa, and measured total stimulated saliva production. We correlated our results with epidemiological, phenotypic, and genotypic findings. Patients with associated diseases or drug therapy causing xerostomia were excluded. Results: We evaluated 25 patients (20 men, mean age 52 years) over a period of 6 months. No patient complained of xerostomia and pigmentation was not detected in the oral mucosa. The total stimulated salivary flow was reduced in 9 patients who had an average ferritin level of 796.5 ?g/l. The decline in total stimulated salivary flow was significantly correlated with ferritin levels (p=0.002). Patients with ferritin levels within the normal range also had normal stimulated salivary flow. Conclusions: We found no pigmented lesions in the oral mucosa; however, we did observe a decrease in total stimulated salivary flow that correlated with ferritin levels. Therefore, hyposialia caused by functional impairment of the salivary glands may be an early marker of iron deposition. © Medicina Oral S. L. es
dc.title Study of total stimulated saliva flow and hyperpigmentation in the oral mucosa of patients diagnosed with hereditary hemochromatosis. Series of 25 cases es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17206 es
dc.type.hasVersion VoR es_ES

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