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Factors related to late stage diagnosis of oral squamous cell carcinoma

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Factors related to late stage diagnosis of oral squamous cell carcinoma

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dc.contributor.author Seoane Romero, Juan M. es
dc.contributor.author Vázquez Mahía, I. es
dc.contributor.author Seoane Lestón, Juan Manuel es
dc.contributor.author Varela Centelles, Pablo Ignacio es
dc.contributor.author Tomás Carmona, Inmaculada es
dc.contributor.author López-Cedrún Cembranos, José Luis es
dc.date.accessioned 2017-07-26T06:39:15Z
dc.date.available 2017-07-26T06:39:15Z
dc.date.issued 2012 es
dc.identifier.citation Seoane Romero, Juan M. ; Vázquez Mahía, I. ; Seoane Lestón, Juan Manuel ; Varela Centelles, Pablo Ignacio ; Tomás Carmona, Inmaculada ; López-Cedrún Cembranos, José Luis. Factors related to late stage diagnosis of oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 1 2012: 15- es
dc.identifier.uri http://hdl.handle.net/10550/60016
dc.description.abstract Aims: To identify factors related to advanced-stage diagnosis of oral cancer to disclose high-risk groups and facilitate early detection strategies. Study design: An ambispective cohort study on 88 consecutive patients treated from January 1998 to December 2003. Inclusion criteria: pathological diagnosis of OSCC (primary tumour) at any oral site and suffering from a tumour at any TNM stage. Variables considered: age, gender, smoking history, alcohol usage, tumour site, macroscopic pattern of the lesion, co-existing precancerous lesion, degree of differentiation, diagnostic delay and TNM stage. Results: A total of 88 patients (mean age 60±11.3; 65.9% males) entered the study. Most patients (54.5%) suffered no delayed diagnosis and 45.5% of the carcinomas were diagnosed at early stages (I-II). The most frequent clinical lesions were ulcers (70.5%). Most cases were well- and moderately-differentiated (91%). Univariate analyses revealed strong associations between advanced stages and moderate-poor differentiation (OR=4.2; 95%CI=1.6-10.9) or tumour site (floor of the mouth (OR=3.6; 95%CI=1.2-11.1); gingivae (OR=8.8; 95%CI=2.0-38.2); and retromolar trigone (OR=8.8; 95%CI=1.5-49.1)). Regression analysis recognised the site of the tumour and the degree of differentiation as significantly associated to high risk of late-stage diagnosis. Conclusions: Screening programmes designed to detect asymptomatic oral cancers should be prioritized. Educational interventions on the population and on the professionals should include a sound knowledge of the disease presentation, specifically on sites like floor of the mouth, gingivae and retromolar trigone. More studies are needed in order to analyse the part of tumour biology on the extension of the disease at the time of diagnosis. © Medicina Oral S. L. es
dc.title Factors related to late stage diagnosis of oral squamous cell carcinoma es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17399 es
dc.type.hasVersion VoR es_ES

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