NAGIOS: RODERIC FUNCIONANDO

Angiogenesis of Oral Lichen Planus : a possible pathogenetic mechanism

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Angiogenesis of Oral Lichen Planus : a possible pathogenetic mechanism

Mostra el registre parcial de l'element

dc.contributor.author Scardina, G.A. es
dc.contributor.author Ruggieri, Alessia es
dc.contributor.author Messina, P. es
dc.contributor.author Maresi, Emiliano es
dc.date.accessioned 2017-09-07T09:02:10Z
dc.date.available 2017-09-07T09:02:10Z
dc.date.issued 2009 es
dc.identifier.citation Scardina, G.A. ; Ruggieri, Alessia ; Messina, P. ; Maresi, Emiliano. Angiogenesis of Oral Lichen Planus : a possible pathogenetic mechanism. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 14 11 2009: 1- es
dc.identifier.uri http://hdl.handle.net/10550/60608
dc.description.abstract Objective: Oral Lichen Planus (OLP) is a chronic inflammatory disease with an autoimmune inflammatory pathogenesis. The aim of the research is to compare the vascular endothelial growth factor (VEGF) and adhesion of molecules in the biopsy samples of patients affected by OLP, in order to research the presence of the angiogenetic phenomenon and to understand its pathogenetic mechanism. Materials and Methods: Thirty OLP patients and thirty healthy subjects were enrolled in a study. The immunohistochemical analysis of the VEGF and vascularendothelial adhesion molecules was carried out by means of primary antibodies and anti-CD34, anti-VEGF, antiCD106 antigen (VCAM-1) and anti-CD54 antigen (ICAM-1). The statistical significance of the differences was checked with the Mann-Whitney test (MW test). The level of significance was set to P<0.001. Data analysis was carried out with StatView 5.0.1 (SAS Institute Inc., Cary, NC). Results: The results reveal the presence of a significant angiogenesis in OLP patients for the VEGF, CD34, CD106 and CD54 (P < 0.001).. The number of vessels in the biopsies of the patients with OLP (mean±SD: 21.27±4.85), compared with the healthy subjects (mean±SD: 4.74±0.97) was significantly more (Mann-Whitney test, P < 0.001). The positive expression rate of VEGF, CD34, VCAM-1 and ICAM-1 in oral lichen samples was 64.2%, 54.3%, 32.5% and 29.7%, respectively. Isolated endothelial cells and newly-formed micro-vessels and endothelial cells with high-immune-positivity to the antibodies anti-ICAM-1 and anti-VCAM-1 were observed. Conclusions: The results of our immunohistochemical research show that a significant neoangiogenesis occurs in oral lichen planus. es
dc.title Angiogenesis of Oral Lichen Planus : a possible pathogenetic mechanism es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.14.e558 es
dc.type.hasVersion VoR es_ES

Visualització       (403.5Kb)

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques