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Influence of hydrophobic matching on association of model transmembrane fragments containing a minimised glycophorin A dimerisation motif

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Influence of hydrophobic matching on association of model transmembrane fragments containing a minimised glycophorin A dimerisation motif

dc.contributor.author	Orzáez Calatayud, María del Mar
dc.contributor.author	Lukovic, Dunja
dc.contributor.author	Abad Mazario, Concepción
dc.contributor.author	Pérez Payá, Enrique
dc.contributor.author	Mingarro Muñoz, Ismael
dc.date.accessioned	2018-04-13T14:32:33Z
dc.date.available	2018-04-13T14:32:33Z
dc.date.issued	2005
dc.identifier.citation	Orzáez Calatayud, María del Mar Lukovic, Dunja Abad Mazario, Concepción Pérez Payá, Enrique Mingarro Muñoz, Ismael 2005 Influence of hydrophobic matching on association of model transmembrane fragments containing a minimised glycophorin A dimerisation motif Febs Letters 579 7 1633 1638
dc.identifier.uri	http://hdl.handle.net/10550/65663
dc.description.abstract	The principles that govern the folding and packing of membrane proteins are still not completely understood. In the present work, we have revisited the glycophorin A (GpA) dimer- isation motif that mediates transmembrane (TM) helix associa- tion, one of the best-suited models of membrane protein oligomerisation. By using artificial polyleucine TM segments we have demonstrated in this study that a pattern of only five amino acids (GVxxGVxxT) promotes specific dimerisation. Fur- ther, we have used this minimised GpA motif to assess the influ- ence of hydrophobic matching on the TM helix packing process in detergent micelles and found that this factor modulates helix-helix association and/or dissociation between TM fragments.
dc.language.iso	eng
dc.relation.ispartof	Febs Letters, 2005, vol. 579, num. 7, p. 1633-1638
dc.subject	Proteïnes de membrana
dc.title	Influence of hydrophobic matching on association of model transmembrane fragments containing a minimised glycophorin A dimerisation motif
dc.type	journal article	es_ES
dc.date.updated	2018-04-13T14:32:33Z
dc.identifier.doi	10.1016/j.febslet.2005.01.078
dc.identifier.idgrec	026410
dc.rights.accessRights	open access	es_ES