NAGIOS: RODERIC FUNCIONANDO

Influence of the C‐terminus of the glycophorin A transmembrane fragment on the dimerization process

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Influence of the C‐terminus of the glycophorin A transmembrane fragment on the dimerization process

Mostra el registre parcial de l'element

dc.contributor.author Orzáez Calatayud, María del Mar
dc.contributor.author Pérez Payá, Enrique
dc.contributor.author Mingarro Muñoz, Ismael
dc.date.accessioned 2018-04-17T14:03:51Z
dc.date.available 2018-04-17T14:03:51Z
dc.date.issued 2000
dc.identifier.citation Orzáez Calatayud, María del Mar Pérez Payá, Enrique Mingarro Muñoz, Ismael 2000 Influence of the C‐terminus of the glycophorin A transmembrane fragment on the dimerization process Protein Science 9 6 1246 1253
dc.identifier.uri http://hdl.handle.net/10550/65752
dc.description.abstract The monomer-dimer equilibrium of the glycophorin A (GpA) transmembrane (TM) fragment has been used as a model system to investigate the amino acid sequence requirements that permit an appropriate helix-helix packing in a membrane‐mimetic environment. In particular, we have focused on a region of the helix where no crucial residues for packing have been yet reported. Various deletion and replacement mutants in the C‐terminal region of the TM fragment showed that the distance between the dimerization motif and the flanking charged residues from the cytoplasmic side of the protein is important for helix packing. Furthermore, selected GpA mutants have been used to illustrate the rearrangement of TM fragments that takes place when leucine repeats are introduced in such protein segments. We also show that secondary structure of GpA derivatives was independent from dimerization, in agreement with the two‐stage model for membrane protein folding and oligomerization.
dc.language.iso eng
dc.relation.ispartof Protein Science, 2000, vol. 9, num. 6, p. 1246-1253
dc.subject Proteïnes de membrana
dc.title Influence of the C‐terminus of the glycophorin A transmembrane fragment on the dimerization process
dc.type journal article es_ES
dc.date.updated 2018-04-17T14:03:51Z
dc.identifier.doi 10.1110/ps.9.6.1246
dc.identifier.idgrec 003978
dc.rights.accessRights open access es_ES

Visualització       (328.9Kb)

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques