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Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs

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Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs

dc.contributor.author	Bologna Molina, Ronell	es
dc.contributor.author	Pereira Prado, Vanesa	es
dc.contributor.author	Sánchez-Romero, Celeste	es
dc.contributor.author	Tapia-Repetto, Gabriel	es
dc.contributor.author	Soria, Sandra	es
dc.contributor.author	Hernandez, Marcela	es
dc.contributor.author	González González, Rogelio	es
dc.contributor.author	Molina Frechero, Nelly	es
dc.contributor.author	Mikami, Toshinari	es
dc.date.accessioned	2018-05-23T08:27:53Z
dc.date.available	2018-05-23T08:27:53Z
dc.date.issued	2018	es
dc.identifier.citation	Bologna Molina, Ronell ; Pereira Prado, Vanesa ; Sánchez-Romero, Celeste ; Tapia-Repetto, Gabriel ; Soria, Sandra ; Hernandez, Marcela ; González González, Rogelio ; Molina Frechero, Nelly ; Mikami, Toshinari. Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 2 2018: 2-	es
dc.identifier.uri	http://hdl.handle.net/10550/66298
dc.description.abstract	Mismatch repair proteins (MMRPs) are a group of nuclear enzymes that participate in the repair of base mismatches that occur during DNA replication in all proliferating cells. The most studied MMRPs are hMSH2 and hMLH1, which are known to be highly expressed in normal tissues. A loss of MMRPs leads to the accumulation of DNA replication errors in proliferating cells. Ki-67 is a biomarker regarded to be the gold-standard tool for determining cell proliferation by immunohistochemical methods. The aim of this study was to investigate the immunohistochemical expression of hMLH1, hMSH2 and Ki-67 proteins in ameloblastomas and tooth germs, to contribute to the understanding of the development of this odontogenic neoplasm. Immunohistochemical assays to determine the presence of proteins hMSH2, hMLH1 and Ki-67 were performed in 80 ameloblastomas (40 solid and 40 unicystic) and five tooth germs. Unicystic ameloblastomas showed higher MMRP expression (hMLH1: 62.5 ± 43.4; hMSH2: 83.3 ± 47.8) than did solid ameloblastomas (hMLH1: 59.4 ± 13.5; hMSH2: 75.8 ± 40.2). Additionally, the cell proliferation index assessed by Ki-67 was inversely proportional to the expression of MMRP. Comparison between tooth germs and ameloblastoma revealed significantly higher expression of hMLH1, hMSH2 and Ki-67 in tooth germs (p=0.02). The differences of MMRP and Ki-67 immunoexpression between ameloblastomas and tooth germ suggest that alterations in the MMRP mechanisms could participate in the biological behavior of ameloblastomas.	es
dc.title	Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.22210	es
dc.type.hasVersion	VoR	es_ES