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Association of liver enzyme levels and alveolar bone loss : a cross-sectional clinical study in Sado Island

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Association of liver enzyme levels and alveolar bone loss : a cross-sectional clinical study in Sado Island

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dc.contributor.author Kuroki, Ayumi es
dc.contributor.author Sugita, Noriko es
dc.contributor.author Komatsu, Shigeki es
dc.contributor.author Yokoseki, Akio es
dc.contributor.author Yoshihara, Akihiro es
dc.contributor.author Kobayashi, Tetsuo es
dc.contributor.author Nakamura, Kazutoshi es
dc.contributor.author Momotsu, Takeshi es
dc.contributor.author Endo, Naoto es
dc.contributor.author Sato, Kenji es
dc.contributor.author Narita, Ichiei es
dc.contributor.author Yoshie, Hiromasa es
dc.date.accessioned 2018-05-23T09:25:45Z
dc.date.available 2018-05-23T09:25:45Z
dc.date.issued 2018 es
dc.identifier.citation Kuroki, Ayumi ; Sugita, Noriko ; Komatsu, Shigeki ; Yokoseki, Akio ; Yoshihara, Akihiro ; Kobayashi, Tetsuo ; Nakamura, Kazutoshi ; Momotsu, Takeshi ; Endo, Naoto ; Sato, Kenji ; Narita, Ichiei ; Yoshie, Hiromasa. Association of liver enzyme levels and alveolar bone loss : a cross-sectional clinical study in Sado Island. En: Journal of Clinical and Experimental Dentistry, 10 2 2018: 100-106 es
dc.identifier.uri http://hdl.handle.net/10550/66333
dc.description.abstract The interaction of periodontopathic bacteria with host immune system induces the production of inflammatory mediators which leads to alveolar bone loss (ABL), the essential feature of periodontitis. Concurrently, periodontal diseases cause the elevation of blood cytokine levels, the alteration of gut microbiota and the dissemination of enterobacteria to the liver. Owing to these mechanisms, periodontal disease might be a risk for liver dysfunction. Several epidemiological studies have reported associations between periodontal diseases and liver dysfunction, although the association between ABL and liver dysfunction has not been investigated. This cross-sectional study determined if elevated serum liver enzyme levels were associated with ABL in Japanese adults. Japanese adults living on Sado Island who visited Sado General Hospital were invited to participate in the study. Participants over 40 years of age who underwent dental panoramic radiography and blood tests were included. Drinking and smoking habits were self-administered. After excluding patients with edentulous jaw, diagnosed liver diseases, and those on dialysis, data from 44 men and 66 women with a mean age of 73 years were analyzed. The average percentage of ABL for each participant was calculated for mesial and distal sites of all remaining teeth. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were determined. Univariate analyses were performed to select covariates to be put in multivariate analyses. The association between elevated serum liver enzyme levels and the highest quartile of ABL were assessed by multiple logistic regression analysis. After adjusting for covariates, no significant association was found between elevated serum AST, ALT, or GGT levels as dependent variables and the highest quartile of ABL as an explanatory variable. There was no significant association between the elevation of serum liver enzyme levels and ABL in Japanese adults. es
dc.title Association of liver enzyme levels and alveolar bone loss : a cross-sectional clinical study in Sado Island es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.54555 es
dc.type.hasVersion VoR es_ES

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