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Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

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Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

dc.contributor.author	Catalá López, Ferran
dc.contributor.author	Hutton, Brian
dc.contributor.author	Driver, JA
dc.contributor.author	Ridao, Manuel
dc.contributor.author	Valderas, Jose Maria
dc.contributor.author	Gènova Maleras, Ricard
dc.contributor.author	Forés Martos, Jaume
dc.contributor.author	Alonso Arroyo, Adolfo
dc.contributor.author	Macías Saint-Gerons, Diego
dc.contributor.author	Vieta, Eduard
dc.contributor.author	Valencia, Alfonso
dc.contributor.author	Tabarés Seisdedos, Rafael
dc.date.accessioned	2018-09-04T08:10:00Z
dc.date.available	2018-09-04T08:10:00Z
dc.date.issued	2017
dc.identifier.citation	Catalá López, Ferran Hutton, Brian Driver, JA Ridao, Manuel Valderas, Jose Maria Gènova Maleras, Ricard Forés Martos, Jaume Alonso Arroyo, Adolfo Macías Saint Gerons, Diego Vieta, Eduard Valencia, Alfonso Tabarés Seisdedos, Rafael 2017 Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies Systematic Reviews 6 137
dc.identifier.uri	http://hdl.handle.net/10550/67386
dc.description.abstract	Background: Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include genetic predisposition, hormonal changes and a combination of environmental, psychosocial, and cultural factors. Cancer is the second leading cause of death worldwide. At present, no systematic reviews and meta-analyses have evaluated the risk of cancer in people with anorexia nervosa. The objective of this study will be to evaluate the association between anorexia nervosa and the risk of developing or dying from cancer. Methods/design: This study protocol is part of a systematic collection and assessment of multiple systematic reviews and meta-analyses (umbrella review) evaluating the association of cancer and multiple central nervous system disorders. We designed a specific protocol for a new systematic review and meta-analysis of observational studies of anorexia nervosa with risk of developing or dying from any cancer. Data sources will be PubMed, Embase, Scopus, Web of Science, and manual screening of references. Observational studies (case-control and cohort) in humans that examined the association between anorexia nervosa and risk of developing or dying from cancer will be sought. The primary outcomes will be cancer incidence and cancer mortality in association with anorexia nervosa. Secondary outcomes will be sitespecific cancer incidence and mortality, respectively. Screening of abstracts and full texts, and data abstraction will be performed by two team members independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. The quality of studies will be assessed by using the Ottawa-Newcastle scale by two team members independently. Random effects models will be conducted where appropriate. Subgroup and additional analyses will be conducted to explore the potential sources of heterogeneity. TheWorld Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes. Discussion: Findings from this systematic review will inform an ongoing umbrella review on cancer and central nervous system disorders. Our systematic review and meta-analysis of observational studies will establish the extent of the epidemiological evidence underlying the association between anorexia nervosa and cancer.
dc.language.iso	eng
dc.relation.ispartof	Systematic Reviews, 2017, num. 6, p. 137
dc.subject	anorexia nerviosa
dc.subject	Cáncer
dc.subject	bibliometría
dc.title	Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
dc.type	journal article	es_ES
dc.date.updated	2018-09-04T08:10:01Z
dc.identifier.doi	10.1186/s13643-017-0540-5.
dc.identifier.idgrec	121334
dc.rights.accessRights	open access	es_ES