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Application of nano-hydroxyapatite/chitosan scaffolds on rat calvarial critical-sized defects : a pilot study

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Application of nano-hydroxyapatite/chitosan scaffolds on rat calvarial critical-sized defects : a pilot study

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dc.contributor.author Chatzipetros, Emmanouil es
dc.contributor.author Christopoulos, Panos es
dc.contributor.author Donta, Catherine es
dc.contributor.author Tosios, Konstantinos I. es
dc.contributor.author Tsiambas, Evangelos es
dc.contributor.author Tsiourvas, Dimitris es
dc.contributor.author Kalogirou, Eleni Marina es
dc.contributor.author Tsiklakis, Kostas es
dc.date.accessioned 2018-11-27T08:34:53Z
dc.date.available 2018-11-27T08:34:53Z
dc.date.issued 2018 es
dc.identifier.citation Chatzipetros, Emmanouil ; Christopoulos, Panos ; Donta, Catherine ; Tosios, Konstantinos I. ; Tsiambas, Evangelos ; Tsiourvas, Dimitris ; Kalogirou, Eleni Marina ; Tsiklakis, Kostas. Application of nano-hydroxyapatite/chitosan scaffolds on rat calvarial critical-sized defects : a pilot study. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 5 2018: 4- es
dc.identifier.uri http://hdl.handle.net/10550/68056
dc.description.abstract The purpose of this pilot study was to evaluate for the first time the effect of 75/25 w/w nano-Hydroxyapatite/Chitosan (nHAp/CS) scaffolds on Guided Bone Regeneration (GBR) in rat calvarial critical-sized defects (CSDs). Six adult Sprague Dawley rats, 3 males and 3 females, were used. Two CSDs, full thickness and 5mm in diameter, were trephined in both sides of the parietal bone. The right CSD was filled with nHAp/CS scaffold, while the left CSD remained empty, as the control group. The wound was sutured in layers. Rats were euthanized with diethyl ether inhalation at 2, 4 and 8 weeks after surgical procedure. Histological and histomorphometric analysis was performed within distinct regions of interest (ROI): the lateral area inward of the middle sagittal seam; the lateral area outward of the middle sagittal seam and the central area. The mean surface of newly formed bone (in ?m2) in the lateral area inward of the middle sagittal seam of all rats was significantly higher (P=0.039) in the experimental group (91733.00±38855.60) than the control group (46762.17±25507.97). The NOex-c, defined as total number of osteocytes (OST) in newly formed bone surface in experimental group [experimental OST] minus the total number of osteocytes in newly formed bone surface in control group [control OST], was significantly greater (P=0.029) at 4th week post-surgery. Within the experimental group, a statistically significant increase (P=0.042) in the surface of newly formed bone was noticed in rats euthanized in 4th week compared with rats euthanized in 2nd week after surgery in the lateral area inward of the middle sagittal seam. The results of this study suggest that 75/25 w/w nHAp/CS scaffolds should be considered as a suitable biomaterial for GBR. es
dc.title Application of nano-hydroxyapatite/chitosan scaffolds on rat calvarial critical-sized defects : a pilot study es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22455 es
dc.type.hasVersion VoR es_ES

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