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The smokeless tobacco habit and DNA damage : a systematic review and meta-analysis

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The smokeless tobacco habit and DNA damage : a systematic review and meta-analysis

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dc.contributor.author de Geus, Juliana-Larocca es
dc.contributor.author Wambier, Letícia-Maíra es
dc.contributor.author Dourado Loguercio, Alessandro es
dc.contributor.author Reis, Alessandra es
dc.date.accessioned 2019-04-15T10:50:09Z
dc.date.available 2019-04-15T10:50:09Z
dc.date.issued 2019 es
dc.identifier.citation de Geus, Juliana-Larocca ; Wambier, Letícia-Maíra ; Dourado Loguercio, Alessandro ; Reis, Alessandra. The smokeless tobacco habit and DNA damage : a systematic review and meta-analysis. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 2 2019: 13- es
dc.identifier.uri http://hdl.handle.net/10550/69963
dc.description.abstract The aim of this systematic review was to evaluate the frequency of micronuclei or other DNA damage in the oral mucosa of adults that have smokeless tobacco habits compared to adults that not have these habits. We searched PubMed, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE. We also surveyed gray literature. We included only clinical trials that compare the frequency of micronuclei or other DNA damage in the oral mucosa of adults that have smokeless tobacco habits compared to adults that not have these habits. Quality assessments of the selected trials were evaluated by two independent reviewers, using the Effective Public Health Practice Project ? (EPHPP) with modifications. After the database screening and removal of duplicates, 2574 studies were identified. After title screening, 172 studies remained, and this number was reduced to 25 after careful examination of the abstracts. The standardized mean difference of the frequency of micronuclei between groups was 1.88, with a 95% confidence interval of 1.40 to 2.36 (p< 0.00001). In all analyses heterogeneity was detected. Despite the heterogeneity of studies, the frequency of micronuclei was significant bigger in adults who have the smokeless tobacco habit when compared to those not have this habit. The same occurred with the frequency of binucleated cells, karyolisis and karyorrhexis. es
dc.title The smokeless tobacco habit and DNA damage : a systematic review and meta-analysis es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22846 es
dc.type.hasVersion VoR es_ES

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