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Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

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Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

dc.contributor.author	Lee, Peter
dc.contributor.author	Calvo, Conrado J.
dc.contributor.author	Alfonso-Almazán, José M.
dc.contributor.author	Quintanilla, Jorge G.
dc.contributor.author	Chorro Gascó, Francisco Javier
dc.contributor.author	Yan, Ping
dc.contributor.author	Loew, Leslie M.
dc.contributor.author	Filgueiras-Rama, David
dc.contributor.author	Millet, José
dc.date.accessioned	2019-06-17T07:10:26Z
dc.date.available	2019-06-17T07:10:26Z
dc.date.issued	2017
dc.identifier.citation	Lee, Peter Calvo, Conrado J. Alfonso-Almazán, José M. Quintanilla, Jorge G. Chorro Gascó, Francisco Javier Yan, Ping Loew, Leslie M. Filgueiras-Rama, David Millet, José 2017 Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models Scientific Reports 7 43217 1 14
dc.identifier.uri	https://hdl.handle.net/10550/70440
dc.description.abstract	Panoramic optical mapping is the primary method for imaging electrophysiological activity from the entire outer surface of Langendorff-perfused hearts. To date, it is the only method of simultaneously measuring multiple key electrophysiological parameters, such as transmembrane voltage and intracellular free calcium, at high spatial and temporal resolution. Despite the impact it has already had on the fields of cardiac arrhythmias and whole-heart computational modeling, present-day system designs precludes its adoption by the broader cardiovascular research community because of their high costs. Taking advantage of recent technological advances, we developed and validated low-cost optical mapping systems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant model in basic research and bioengineering. By significantly lowering financial thresholds, this powerful cardiac electrophysiology imaging modality may gain wider use in research and, even, teaching laboratories, which we substantiated using the lower-cost Langendorff-perfused rabbit heart model.
dc.language.iso	cat
dc.relation.ispartof	Scientific Reports, 2017, vol. 7, num. 43217, p. 1-14
dc.subject	Fisiologia
dc.subject	Cor Malalties
dc.subject	Bioenginyeria
dc.subject	Sistema cardiovascular
dc.subject	Diagnòstic per la imatge
dc.title	Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models
dc.type	journal article	es_ES
dc.date.updated	2019-06-17T07:10:26Z
dc.identifier.doi	10.1038/srep43217
dc.identifier.idgrec	133424
dc.rights.accessRights	open access	es_ES