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Antibiotic prophylaxis for the prevention of infective endocarditis for dental procedures is not associated with fatal adverse drug reactions in France

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Antibiotic prophylaxis for the prevention of infective endocarditis for dental procedures is not associated with fatal adverse drug reactions in France

dc.contributor.author	Cloitre, Alexandra	es
dc.contributor.author	Duval, Xavier	es
dc.contributor.author	Tubiana, Sarah	es
dc.contributor.author	Giraud, Pauline	es
dc.contributor.author	Veyrac, Gwenaëlle	es
dc.contributor.author	Nosbaum, Audrey	es
dc.contributor.author	Gouraud, Aurore	es
dc.contributor.author	Mahé, Julien	es
dc.contributor.author	Lesclous, Philippe	es
dc.date.accessioned	2019-07-02T09:55:58Z
dc.date.available	2019-07-02T09:55:58Z
dc.date.issued	2019	es
dc.identifier.citation	Cloitre, Alexandra ; Duval, Xavier ; Tubiana, Sarah ; Giraud, Pauline ; Veyrac, Gwenaëlle ; Nosbaum, Audrey ; Gouraud, Aurore ; Mahé, Julien ; Lesclous, Philippe. Antibiotic prophylaxis for the prevention of infective endocarditis for dental procedures is not associated with fatal adverse drug reactions in France. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 3 2019: 8-	es
dc.identifier.uri	https://hdl.handle.net/10550/70672
dc.description.abstract	One of the major reasons to stop antibiotic prophylaxis (AP) to prevent infective endocarditis (IE) in the United Kingdom but not in the rest of the world was that it would result in more deaths from fatal adverse drug reactions (ADRs) than the number of IE deaths. The main aim of this study was to quantify and describe the ADRs with amoxicillin or clindamycin for IE AP. The second aim was to infer a crude incidence of anaphylaxis associated with amoxicillin for IE AP. The Medical Dictionary for Regulatory Activities (MedDRA) was used to group ADRs for IE AP using the broad Standardized MedDRA Queries ?Anaphylactic reaction, Amoxicillin, Clindamycin, Clostridium Difficile infection? to the French Pharmacovigilance Database System. From this first-line collection, we selected all cases occurring for IE AP and ultimately, the cases for IE AP for a dental procedure. Then, each case was analyzed. Of 11639 first-line recorded ADRs, 100 were for IE AP but no fatal anaphylaxis to amoxicillin or clindamycin and no C. difficile infection associated with clindamycin were identified. Only 17 cases of anaphylaxis to amoxicillin related to dental procedures were highlighted. The estimation of the crude incidence rate of anaphylaxis associated with amoxicillin for IE AP for invasive dental procedure was 1/57 000 (95% CI 0.2-0.6). Fatal or severe ADRs with amoxicillin or clindamycin is not a rational argument to stop IE AP before invasive dental procedures.	es
dc.title	Antibiotic prophylaxis for the prevention of infective endocarditis for dental procedures is not associated with fatal adverse drug reactions in France	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.22818	es
dc.type.hasVersion	VoR	es_ES