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E-Cadherin gene expression in oral cancer : clinical and prospective data

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E-Cadherin gene expression in oral cancer : clinical and prospective data

dc.contributor.author	López-Verdín, Sandra	es
dc.contributor.author	Martínez-Fierro, Margarita de la Luz	es
dc.contributor.author	Garza Veloz, Idalia	es
dc.contributor.author	Zamora Pérez, Ana Lourdes	es
dc.contributor.author	Grajeda-Cruz, Jonathan	es
dc.contributor.author	González González, Rogelio	es
dc.contributor.author	Molina Frechero, Nelly	es
dc.contributor.author	Arocena, Miguel	es
dc.contributor.author	Bologna Molina, Ronell	es
dc.date.accessioned	2019-11-06T12:51:17Z
dc.date.available	2019-11-06T12:51:17Z
dc.date.issued	2019	es
dc.identifier.citation	López-Verdín, Sandra ; Martínez-Fierro, Margarita de la Luz ; Garza Veloz, Idalia ; Zamora Pérez, Ana Lourdes ; Grajeda-Cruz, Jonathan ; González González, Rogelio ; Molina Frechero, Nelly ; Arocena, Miguel ; Bologna Molina, Ronell. E-Cadherin gene expression in oral cancer : clinical and prospective data. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 4 2019: 16-	es
dc.identifier.uri	https://hdl.handle.net/10550/72056
dc.description.abstract	Low protein expression of E-cadherin in oral squamous cell carcinoma (OSCC) has been associated with clinical and histopathological traits such as metastases, recurrence, low survival and poor tumor differentiation, and it is considered a high-risk marker of malignancy. However, it is still unknown whether low expression of E-cadherin is also present at the mRNA level in OSCC cases. Objective: The aim of this study was to compare E-cadherin mRNA expression in OSCC patients and controls and to correlate the expression with clinical and prospective characteristics. Forty patients and 40 controls were enrolled. E-cadherin mRNA expression was evaluated by quantitative real-time polymerase chain reaction using TaqMan probes. E-cadherin mRNA expression was significantly decreased in OSCC patients compared to that of controls (p<0.001). Whereas no significant association between clinical parameters and E-cadherin expression levels was observed, we noted lower E-cadherin expression levels in patients with positive lymph node metastasis. E-cadherin mRNA expression was markedly diminished in OSCC, in agreement with previous results that examined E-cadherin expression at the protein level. E-cadherin is downregulated in the early clinical stages of OSCC, and its mRNA levels do not change significantly in the advanced stages, suggesting that there is limited usefulness of this parameter for predicting disease progression.	es
dc.title	E-Cadherin gene expression in oral cancer : clinical and prospective data	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23029	es
dc.type.hasVersion	VoR	es_ES