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Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

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Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

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dc.contributor.author	Montesinos Magraner, Marc
dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Cantón, Rubén
dc.contributor.author	Blay Llinares, Gonzalo
dc.contributor.author	Fernández Picot, Isabel
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.date.accessioned	2020-03-30T09:29:55Z
dc.date.available	2020-03-30T09:29:55Z
dc.date.issued	2015
dc.identifier.citation	Montesinos Magraner, Marc Vila Descals, Carlos Cantón, Rubén Blay Llinares, Gonzalo Fernández Picot, Isabel Muñoz, M. Carmen Pedro, José Ramón 2015 Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters Angewandte Chemie 54 6320 6324
dc.identifier.uri	https://hdl.handle.net/10550/73708
dc.description.abstract	A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields (up to 99%) with excellent enantioselectivity (up to 99% ee). To the best of our knowledge, this transformation is the first highly enantioselective addition of naphthols to ketimines.
dc.language.iso	eng
dc.relation.ispartof	Angewandte Chemie, 2015, vol. 54, p. 6320-6324
dc.subject	Química orgànica
dc.subject	Catàlisi
dc.subject	Reaccions químiques
dc.title	Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters
dc.type	journal article	es_ES
dc.date.updated	2020-03-30T09:29:55Z
dc.identifier.doi	10.1002/anie.201501273
dc.identifier.idgrec	102613
dc.rights.accessRights	open access	es_ES