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Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

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Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

dc.contributor.author	Montagud Romero, Sandra
dc.contributor.author	Blanco Gandía, María del Carmen
dc.contributor.author	Reguilón, Marina D.
dc.contributor.author	Ferrer Pérez, Carmen
dc.contributor.author	Ballestín Hinojosa, Raúl
dc.contributor.author	Rodríguez Arias, Marta
dc.contributor.author	Miñarro López, José
dc.date.accessioned	2020-04-28T15:46:54Z
dc.date.available	2020-04-28T15:46:54Z
dc.date.issued	2018
dc.identifier.citation	Montagud Romero, Sandra Blanco Gandía, María del Carmen Reguilón, Marina D. Ferrer Pérez, Carmen Ballestín Hinojosa, Raúl Rodríguez Arias, Marta Miñarro López, José 2018 Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse European Journal of Neuroscience 48 9 2948 2970
dc.identifier.uri	https://hdl.handle.net/10550/74106
dc.description.abstract	Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces long-lasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short- and long-term consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the advantages and disadvantages and the translational value of the social defeat stress model, and will discuss challenges and future directions.
dc.language.iso	eng
dc.relation.ispartof	European Journal of Neuroscience, 2018, vol. 48, num. 9, p. 2948-2970
dc.subject	Psicobiologia
dc.title	Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse
dc.type	journal article	es_ES
dc.date.updated	2020-04-28T15:46:55Z
dc.identifier.doi	10.1111/ejn.14127
dc.identifier.idgrec	127071
dc.rights.accessRights	open access	es_ES