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Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain

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Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain

dc.contributor.author	Pérez Ortín, José Enrique
dc.contributor.author	Santiso Bellón, Cristina
dc.contributor.author	Vila Vicent, Susana
dc.contributor.author	Carmona Vicente, Noelia
dc.contributor.author	Rodríguez Díaz, Jesús
dc.contributor.author	Buesa Gómez, Javier
dc.date.accessioned	2020-06-09T08:27:10Z
dc.date.available	2020-06-09T08:27:10Z
dc.date.issued	2019
dc.identifier.citation	Pérez Ortín, José Enrique Santiso Bellón, Cristina Vila Vicent, Susana Carmona Vicente, Noelia Rodríguez Díaz, Jesús Buesa Gómez, Javier 2019 Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain BMC Infectious Diseases 19 998 1 10
dc.identifier.uri	https://hdl.handle.net/10550/74908
dc.description.abstract	BACKGROUND: Human group A rotavirus is the leading cause of severe acute gastroenteritis in young children worldwide. Immunization programs have reduced the disease burden in many countries. Vaccination coverage in the Autonomous Region of Valencia, Spain, is around 40%, as the rotavirus vaccine is not funded by the National Health System. Despite this low-medium vaccine coverage, rotavirus vaccination has substantially reduced hospitalizations due to rotavirus infection and hospital-related costs. However, there are very few studies evaluating symptomatic rotavirus infections not requiring hospitalization in vaccinated children. The objective of this study was to investigate symptomatic rotavirus infections among vaccinated children in the health area served by the Hospital Clínico Universitario of Valencia, Spain, from 2013 to 2015. METHODS: A total of 133 children younger than 5 years of age with rotavirus infection were studied. Demographic and epidemiological data were collected and informed consent from their caretakers obtained. Rotavirus infection was detected by immunological methods and G/P rotavirus genotypes were determined by RT-PCR, following standard procedures from the EuroRotaNet network. RESULTS: Forty infants (30.1%; 95% CI: 22.3-37.9) out of 133 were diagnosed with symptomatic rotavirus infection despite having been previously vaccinated, either with RotaTeq (85%) or with Rotarix (15%). Children fully vaccinated against rotavirus (24.8%), partially vaccinated (5.3%) and unvaccinated (69.9%) were found. The infecting genotypes showed high G-type diversity, although no significant differences were found between the G/P genotypes infecting vaccinated and unvaccinated children during the same time period. G9P[8], G12P[8] and G1P[8] were the most prevalent genotypes. Severity of gastroenteritis symptoms required 28 (66.6%) vaccinated and 67 (73.6%) unvaccinated children to be attended at the Emergency Room. CONCLUSION: Rotavirus vaccine efficacy in reducing the incidence of severe rotavirus infection has been well documented, but symptomatic rotavirus infection can sometimes occur in vaccinees.
dc.language.iso	eng
dc.relation.ispartof	BMC Infectious Diseases, 2019, vol. 19, num. 998, p. 1-10
dc.subject	Virus RNA
dc.subject	Gastroenterologia
dc.subject	Vacunació
dc.title	Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain
dc.type	journal article	es_ES
dc.date.updated	2020-06-09T08:27:10Z
dc.identifier.doi	10.1186/s12879-019-4550-x
dc.identifier.idgrec	136296
dc.rights.accessRights	open access	es_ES