NAGIOS: RODERIC FUNCIONANDO

Correction to: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial.

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Correction to: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial.

dc.contributor.author	Kiss, T.
dc.contributor.author	Wittenstein, J.
dc.contributor.author	Becker, C.
dc.contributor.author	Birr, K.
dc.contributor.author	Cinnella, G.
dc.contributor.author	Cohen, E.
dc.contributor.author	El Tahan, M.R.
dc.contributor.author	Falcão, L.F.
dc.contributor.author	Gregoretti, C.
dc.contributor.author	Granell Gil, Manuel
dc.contributor.author	Hachenberg, T.
dc.contributor.author	Hollmann, M.W.
dc.contributor.author	Jankovic, R.
dc.contributor.author	Karzai, W.
dc.contributor.author	Krassler, J.
dc.contributor.author	Loop, T.
dc.contributor.author	Licker, M.J.
dc.contributor.author	Marczin, N.
dc.contributor.author	Mills, G.H.
dc.contributor.author	Murrell, M.T.
dc.contributor.author	Neskovic, V.
dc.contributor.author	Nisnevitch-Savarese, Z.
dc.contributor.author	Pelosi, P.
dc.contributor.author	Rossaint, R.
dc.contributor.author	Schultz, M.J.
dc.contributor.author	Serpa Neto, A.
dc.contributor.author	Severgnini, P.
dc.contributor.author	Szegedi, L.
dc.contributor.author	Vegh, T.
dc.contributor.author	Voyagis, G.
dc.contributor.author	Zhong, J.
dc.contributor.author	Gama de Abreu, M.
dc.contributor.author	Senturk, M.
dc.date.accessioned	2020-07-29T07:22:32Z
dc.date.available	2020-07-29T07:22:32Z
dc.date.issued	2019
dc.identifier.citation	Kiss, T. Wittenstein, J. Becker, C. Birr, K. Cinnella, G. Cohen, E. El Tahan, M.R. Falcão, L.F. Gregoretti, C. Granell Gil, Manuel Hachenberg, T. Hollmann, M.W. Jankovic, R. Karzai, W. Krassler, J. Loop, T. Licker, M.J. Marczin, N. Mills, G.H. Murrell, M.T. Neskovic, V. Nisnevitch-Savarese, Z. Pelosi, P. Rossaint, R. Schultz, M.J. Serpa Neto, A. Severgnini, P. Szegedi, L. Vegh, T. Voyagis, G. Zhong, J. Gama de Abreu, M. Senturk, M. 2019 Correction to: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial. Trials 20 1 259
dc.identifier.uri	https://hdl.handle.net/10550/75386
dc.description.abstract	Background: Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM. Methods: PROTHOR is an international, multicenter, randomized, controlled, assessor-blinded, two-arm trial initiated by investigators of the PROtective VEntilation NETwork. In total, 2378 patients will be randomly assigned to one of two different intraoperative mechanical ventilation strategies. Investigators screen patients aged 18 years or older, scheduled for open thoracic or video-assisted thoracoscopic surgery under general anesthesia requiring OLV, with a maximal body mass index of 35 kg/m2 , and a planned duration of surgery of more than 60 min. Further, the expected duration of OLV shall be longer than two-lung ventilation, and lung separation is planned with a double lumen tube. Patients will be randomly assigned to PEEP of 10 cmH2O with lung RM, or PEEP of 5 cmH2O without RM. During two-lung ventilation tidal volume is set at 7 mL/kg predicted body weight and, during OLV, it will be decreased to 5 mL/kg. The occurrence of PPC will be recorded as a collapsed composite of single adverse pulmonary events and represents the primary endpoint. Discussion: PROTHOR is the first randomized controlled trial in patients undergoing thoracic surgery with OLV that is adequately powered to compare the effects of intraoperative high PEEP with RM versus low PEEP without RM on PPC. The results of the PROTHOR trial will support anesthesiologists in their decision to set intraoperative PEEP during protective ventilation for OLV in thoracic surgery.
dc.language.iso	eng
dc.relation.ispartof	Trials, 2019, vol. 20, num. 1, p. 259
dc.subject	Cirurgia
dc.subject	Tòrax
dc.subject	Ventilació
dc.title	Correction to: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial.
dc.type	journal article	es_ES
dc.date.updated	2020-07-29T07:22:32Z
dc.identifier.doi	10.1186/s13063-019-3371-y
dc.identifier.idgrec	140304
dc.rights.accessRights	open access	es_ES