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Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris : correlation with disease severity

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Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris : correlation with disease severity

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dc.contributor.author Delavarian, Zarha es
dc.contributor.author Layegh, Pouran es
dc.contributor.author Pakfetrat, Atessa es
dc.contributor.author Zarghi, Nazila es
dc.contributor.author Khorashadizadeh, Mahboubeh es
dc.contributor.author Ghazi, Ala es
dc.date.accessioned 2020-10-22T11:51:13Z
dc.date.available 2020-10-22T11:51:13Z
dc.date.issued 2020 es
dc.identifier.citation Delavarian, Zarha ; Layegh, Pouran ; Pakfetrat, Atessa ; Zarghi, Nazila ; Khorashadizadeh, Mahboubeh ; Ghazi, Ala. Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris : correlation with disease severity. En: Journal of Clinical and Experimental Dentistry, 12 5 2020: 440-445 es
dc.identifier.uri https://hdl.handle.net/10550/76052
dc.description.abstract Pemphigus is an autoimmune blistering disease of the skin and mucous membranes caused by autoantibodies against desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). Pemphigus vulgaris (PV) is the most common form of pemphigus. The aim of this study was to assess the correlation between the levels of anti-desmoglein 1 and 3 autoantibodies and the severity of PV disease. Nineteen newly diagnosed patients with pemphigus vulgaris were enrolled in this study. The titers of Dsg in subjects by using enzyme-linked immunosorbent assay (ELISA) were done at diagnosis time-point, 4th and 8th weeks after the initiation of treatment, and the correlation of antibodies with the oral and skin disease severity was evaluated. The severity of cutaneous lesions was significantly correlated with anti-Dsg1 titer in all visits and the severity of mucosal lesions was correlated with the titer of Dsg3 in the third visit (<0.001, 0.001, 0.016 and 0.015 P value, respectively). Anti-Dsg-1 autoantibodies titers seem to be more useful in showing the extent of the disease and activity in pemphigus with mucocutaneous lesions. es
dc.title Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris : correlation with disease severity es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.56289 es
dc.type.hasVersion VoR es_ES

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