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Efficacy of ozonized water for the treatment of erosive oral lichen planus : a randomized controlled study

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Efficacy of ozonized water for the treatment of erosive oral lichen planus : a randomized controlled study

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dc.contributor.author Veneri, Federica es
dc.contributor.author Bardellini, Elena es
dc.contributor.author Amadori, Francesca es
dc.contributor.author Conti, Giulio es
dc.contributor.author Majorana, Alessandra es
dc.date.accessioned 2021-01-15T12:29:39Z
dc.date.available 2021-01-15T12:29:39Z
dc.date.issued 2020 es
dc.identifier.citation Veneri, Federica ; Bardellini, Elena ; Amadori, Francesca ; Conti, Giulio ; Majorana, Alessandra. Efficacy of ozonized water for the treatment of erosive oral lichen planus : a randomized controlled study. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 5 2020: 3- es
dc.identifier.uri https://hdl.handle.net/10550/77173
dc.description.abstract Management of erosive Oral Lichen Planus (eOLP) is challenging. Currently, topical corticosteroids are widely used as first-line therapy, but they might be associated with side-effects and incomplete clinical response. Among non-pharmacological strategies, ozone at low medical concentration has proven to induce a mild activation of protective anti-oxidant pathways, thus exerting therapeutic effects in many inflammatory diseases. The aim of this randomized controlled study was to investigate the effectiveness of ozonized water in association with conventional topical corticosteroids for the treatment of eOLP. Fifty-one patients were included in the study and randomized into 2 groups: study group (n=26) included patients receiving ozonized water treatment; control group (n=25) included patients receiving placebo treatment (i.e. double-distilled water). Treatment protocol consisted of 1-minute oral rinses, repeated for 4 times, twice a week for 4 weeks. All patients received conventional corticosteroid topical therapy (betamethasone soluble tablets, 2 rinses/day for 4 weeks). Assessment of size of lesions, sign and pain scores was performed before treatment, after 2 weeks of treatment (T1) and at the end of 4-week treatment (T2). Efficacy Index (EI) of treatment, candidiasis and relapse rates were also recorded. All patients experienced significant improvement of sign and pain scores with a higher rate of improvement in ozone-treated group (T1 improvement rates: Thongprasom 92.2% vs 28%; VAS pain 76.9% vs 32%; p<0.05). Pain and size reduction were significantly higher in ozone-treated group both at T1 and T2 (p<0.05). Ozone-treated group showed a higher EI at every time point (T0-T2: 72.77% vs 37.66%, p<0.01). Candidiasis (32% vs 11.5%) and relapse (40% vs 34.6%) rates were higher in control group, however the differences were not statistically significant. Within the limitations of this study, ozonized water seems to be effective as an adjunct therapy, in combination with topical corticosteroids, for the treatment of eOLP. es
dc.title Efficacy of ozonized water for the treatment of erosive oral lichen planus : a randomized controlled study es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23693 es
dc.type.hasVersion VoR es_ES

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