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Myofibroblasts and increased angiogenesis contribute to periapical cystic injury containment and repair

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Myofibroblasts and increased angiogenesis contribute to periapical cystic injury containment and repair

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dc.contributor.author de-Freitas, Camila Tatyanne Santos es
dc.contributor.author de-França, Glória Maria es
dc.contributor.author Gordón Nuñez, Manuel Antonio es
dc.contributor.author Santos, Pedro-Paulo-de Andrade es
dc.contributor.author Costa de Lima, Kenio es
dc.contributor.author Galvão, Hébel Cavalcanti es
dc.date.accessioned 2021-01-15T12:29:40Z
dc.date.available 2021-01-15T12:29:40Z
dc.date.issued 2020 es
dc.identifier.citation de-Freitas, Camila Tatyanne Santos ; de-França, Glória Maria ; Gordón Nuñez, Manuel Antonio ; Santos, Pedro-Paulo-de Andrade ; Costa de Lima, Kenio ; Galvão, Hébel Cavalcanti. Myofibroblasts and increased angiogenesis contribute to periapical cystic injury containment and repair. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 5 2020: 4- es
dc.identifier.uri https://hdl.handle.net/10550/77174
dc.description.abstract Myofibroblasts (MF) and angiogenesis are important factors in the development and expansion of cystic lesions, where these cells secrete growth factors and proteases, stimulating angiogenesis, matrix deposition and cell migration, affecting the growth of these periapicopathies. The present study aimed to evaluate the immunohistochemical expression of CD34 and ?-SMA in radicular cysts (RC) and residual radicular cysts (RRC), with the purpose of contributing to a better understanding of the expansion and progression of these periapical lesions. The present study os a descriptive, quantitative and comparative analysis of positive CD34 and ?-SMA immunohistochemical expressions in 30 RC and 30 RRC specimens. ?-SMA expression was evaluated in the fibrous capsule of the lesions, at 100x magnification below the epithelial lining. A total of 10 higher immunostaining fields were selected and subsequently, positive cells were quantified at 400x magnification, averaged per field. Regarding the angiogenic index, immuno-labeled microvessel counts for the anti-CD34 antibody were performed in 10 fields at 200x magnification. Statistically significant differences regarding ?-SMA immunostaining were observed (p = 0.035), as well as a correlation between ?-SMA versus CD34 (p = 0.004) in RRC. However, the angiogenic index obtained by immunostaining for CD34 indicated no statistical difference between lesions. Intense inflammatory infiltrates were predominant in RC, while mild and moderate degrees were more commonly observed in RRC (p <0.001). Intense inflammatory infiltrates were also more often noted in larger RRC (p = 0.041). Inflammatory infiltrates showed no significant correlation with ?-SMA and CD34 immunostaining. The results indicate that the significant correlation found between the presence of MF and the angiogenic index are related to the repair process in RRC. es
dc.title Myofibroblasts and increased angiogenesis contribute to periapical cystic injury containment and repair es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23605 es
dc.type.hasVersion VoR es_ES

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