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Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery : a randomized and placebo-controlled clinical trial

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Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery : a randomized and placebo-controlled clinical trial

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dc.contributor.author Sáez Alcaide, Luis Miguel es
dc.contributor.author Molinero Mourelle, Pedro es
dc.contributor.author González Serrano, José es
dc.contributor.author Rubio Alonso, Luis Jesús es
dc.contributor.author Bornstein, Michael M. es
dc.contributor.author López Quiles, Juan es
dc.date.accessioned 2021-01-15T12:29:42Z
dc.date.available 2021-01-15T12:29:42Z
dc.date.issued 2020 es
dc.identifier.citation Sáez Alcaide, Luis Miguel ; Molinero Mourelle, Pedro ; González Serrano, José ; Rubio Alonso, Luis Jesús ; Bornstein, Michael M. ; López Quiles, Juan. Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery : a randomized and placebo-controlled clinical trial. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 5 2020: 10- es
dc.identifier.uri https://hdl.handle.net/10550/77180
dc.description.abstract The aim of this study was to evaluate and compare the postoperative effect of a topic gel containing chlorhexidine, chitosan, allantoine and dexpanthenol versus a placebo for pain and inflammation control after third molar surgery. A gel combining 0.2% chlorhexdine, 0.5% chitosan, 5% dexpanthenol, 0.15% allantoin and 0.01% sodium saccharin was selected for this split mouth randomized controlled and double-blind trial including 36 patients with bilaterally and symmetrically impacted lower third molars. The teeth (n=72) were randomly divided into two groups before surgical removal: control group (CG; in which a placebo was given) and experimental group (EG). Swelling, trismus, postoperative pain, wound healing and complications were measured and recorded in order to evaluate differences between the placebo and experimental product. Five patients suffered from an alveolitis in the CG (13.9%), and none in the study group (0%), but no statistically significant difference was found (p=0.063). From day 0 to day 7, trismus and swelling were significantly less pronounced in the EG, and wound healing was considered ?good? in 22.2% for the CG and 97.2% for the EG (p<0.001). Mean VAS scores during the seven postoperative days were statistically lower in the study (2.56±1,19) compared to the placebo group (3.25±1.6) (p=0.002). The mean consumption of analgesic pills during the first 92 hours was also statistically lower in the EG (0.26±0.51) in comparison to the CG (0.56±0.67) (p=0.003). The use of an experimental gel containing chlorhexidine, chitosan, allantoine and dexpanthenol seems to significantly reduce postoperative pain, trismus and signs of inflammation. Future studies should further evaluate, if the gel is effective in dry socket preventing after third molar removal. es
dc.title Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery : a randomized and placebo-controlled clinical trial es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23661 es
dc.type.hasVersion VoR es_ES

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