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Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy

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Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy

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dc.contributor.author Gutiérrez-Vargas, Rosaura es
dc.contributor.author Villasís-Keever, Miguel Angel es
dc.contributor.author Portilla Robertson, Javier es
dc.contributor.author Ascencio-Montiel, Ivan De Jesús es
dc.contributor.author Zapata-Tarrés, Marta es
dc.date.accessioned 2021-05-04T11:01:17Z
dc.date.available 2021-05-04T11:01:17Z
dc.date.issued 2020 es
dc.identifier.citation Gutiérrez-Vargas, Rosaura ; Villasís-Keever, Miguel Angel ; Portilla Robertson, Javier ; Ascencio-Montiel, Ivan De Jesús ; Zapata-Tarrés, Marta. Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 6 2020: 9- es
dc.identifier.uri https://hdl.handle.net/10550/79083
dc.description.abstract Oropharyngeal mucositis (OM) is one of the main side-effects of oncological therapy. There is no treatment to prevent its occurrence, but some zinc-based therapies have been proven to help in decreasing its intensity. The objective of this study was to determine the effect of zinc in OM in children with acute leukemia in the early stages of oncological treatment. This quasi-experimental study evaluated OM in 2 groups (control group: conventional hospital management, and experimental group: administration of 50 mg of zinc gluconate daily plus conventional hospital management). OM severity was recorded at a two-month follow-up. Forty-nine patients (26 in the control group and 23 in the experimental group) were included. The mean age of the patients was 11.1 ± 2.7 years; 65.3% had a diagnosis of pre-B acute lymphoblastic leukemia. The incidences of OM in the control group and the experimental group were 46.2% and 26.1%, respectively, but the difference was not significant. Based on a negative binomial regression model, females had, on average, 1.5 more days with OM (p = 0.002), and patients assigned to the experimental group had, on average, 2 less days with OM than the control group (p = 0.001). The pain score was higher in the control group (p = 0.0009), as was the mean score on the WHO scale (p = 0.0012). Zinc facilitated a reduction in the severity and duration of OM; further studies focusing on children are needed to confirm the effects of this trace element. es
dc.title Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23798 es
dc.type.hasVersion VoR es_ES

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