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Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients

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Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients

dc.contributor.author	Alcaide García, Julia
dc.contributor.author	Guirado Guillén, Ramón
dc.contributor.author	Crespo Rupérez, Carlos
dc.contributor.author	Blasco Ibáñez, José Miguel
dc.contributor.author	Varea López, Emilio
dc.contributor.author	Sanjuán Arias, Julio
dc.contributor.author	Nácher Roselló, Juan Salvador
dc.date.accessioned	2021-07-29T15:29:14Z
dc.date.available	2021-07-29T15:29:14Z
dc.date.issued	2019
dc.identifier.citation	Alcaide García, Julia Guirado Guillén, Ramón Crespo Rupérez, Carlos Blasco Ibáñez, José Miguel Varea López, Emilio Sanjuán Arias, Julio Nácher Roselló, Juan Salvador 2019 Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients International Journal Of Bipolar Disorders 7 1 24
dc.identifier.uri	https://hdl.handle.net/10550/80083
dc.description.abstract	Background: Alterations in the structure and physiology of interneurons in the prefrontal cortex (PFC) are important factors in the etiopathology of different psychiatric disorders. Among the interneuronal subpopulations, parvalbumin (PV) expressing cells appear to be specially affected. Interestingly, during development and adulthood the connectivity of these interneurons is regulated by the presence of perineuronal nets (PNNs), specialized regions of the extracellular matrix, which are frequently surrounding PV expressing neurons. Previous reports have found anomalies in the density of PNNs in the PFC of schizophrenic patients. However, although some studies have described alterations in PNNs in some extracortical regions of bipolar disorder patients, there are no studies focusing on the prefrontocortical PNNs of bipolar or major depression patients. For this reason, we have analyzed the density of PNNs in post-mortem sections of the dorsolateral PFC (DLPFC) from the Stanley Neuropathology Consortium, which includes controls, schizophrenia, bipolar and major depression patients. Results: We have not observed differences in the distribution of PV+ cells or PNNs, or in the percentage of PV+ interneurons surrounded by PNNs. The density of PV+ interneurons was similar in all the experimental groups, but there was a significantly lower density of PNNs in the DLPFC of bipolar disorder patients and a tendency towards a decrease in schizophrenic patients. No differences were found when evaluating the density of PV+ cells surrounded by PNNs. Interestingly, when assessing the influence of demographic data, we found an inverse correlation between the density of PNNs and the presence of psychosis. Conclusions: The present results point to prefrontocortical PNNs and their role in the regulation of neuronal plasticity as putative players in the etiopathology of bipolar disorder and schizophrenia. Our findings also suggest a link between these specialized regions of the extracellular matrix and the presence of psychosis.
dc.language.iso	spa
dc.relation.ispartof	International Journal Of Bipolar Disorders, 2019, vol. 7, num. 1, p. 24
dc.subject	Salut mental
dc.subject	Esquizofrènia
dc.subject	Psiquiatria
dc.title	Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients
dc.type	journal article	es_ES
dc.date.updated	2021-07-29T15:29:14Z
dc.identifier.doi	10.1186/s40345-019-0161-0
dc.identifier.idgrec	136805
dc.rights.accessRights	open access	es_ES