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Ten millennia of hepatitis B virus evolution

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Ten millennia of hepatitis B virus evolution

dc.contributor.author	Salazar García, Domingo Carlos
dc.contributor.author	Papac, L.
dc.contributor.author	Barquera, R.
dc.contributor.author	Key, F.M.
dc.contributor.author	Spyrou, M.A.
dc.contributor.author	Hübler, R.
dc.contributor.author	Rohrlach, A.B.
dc.contributor.author	Aron, F.
dc.contributor.author	Stahl, R.
dc.contributor.author	Wissgott, A.
dc.contributor.author	van Bömmel, F.
dc.contributor.author	Pfefferkorn, M.
dc.contributor.author	Mittnik, A.
dc.contributor.author	Villalba-Mouco, V.
dc.contributor.author	Neumann, G.U.
dc.contributor.author	Rivollat, M.
dc.contributor.author	van de Loosdrecht, M.S.
dc.contributor.author	Majander, K.
dc.contributor.author	Tukhbatova, R.I.
dc.contributor.author	Musralina, L.
dc.contributor.author	Ghalichi, A.
dc.contributor.author	Penske, S.
dc.contributor.author	Sabin, S.
dc.contributor.author	Michel, M.
dc.contributor.author	Gretzinger, J.
dc.contributor.author	Nelson, E.A.
dc.contributor.author	Ferraz, Tiago
dc.contributor.author	Nägele, Kathrin
dc.contributor.author	Parker, C.
dc.contributor.author	Keller, M.
dc.contributor.author	Guevara, E.K.
dc.contributor.author	Feldman, M.
dc.contributor.author	Eisenmann, S.
dc.contributor.author	Skourtanioti, E.
dc.contributor.author	Giffin, K.
dc.contributor.author	Gnecchi-Ruscone, G.A.
dc.contributor.author	Friederich, S.
dc.contributor.author	Schimmenti, V.
dc.contributor.author	Khartanovich, V.
dc.contributor.author	Karapetian, M.K.
dc.date.accessioned	2021-10-27T08:21:44Z
dc.date.available	2021-10-27T08:21:44Z
dc.date.issued	2021
dc.identifier.citation	Salazar-García, Domingo C. Papac L. Barquera R. Key F.M. Spyrou M.A. Hübler R. Rohrlach A.B. Aron F. Stahl R. Wissgott A. van Bömmel F. Pfefferkorn M. Mittnik A. Villalba-Mouco V. Neumann G.U. Rivollat M. van de Loosdrecht M.S. Majander K. Tukhbatova R.I. Musralina L. Ghalichi A. Penske S. Sabin S. Michel M. Gretzinger J. Nelson E.A. Ferraz T. NÄgele K. Parker C. Keller M. Guevara E.K. Feldman M. Eisenmann S. Skourtanioti E. Giffin K. Gnecchi-Ruscone G.A. Friederich S. Schimmenti V. Khartanovich V. Karapetian M.K. 2021 Ten millennia of hepatitis B virus evolution Science 374 182 188
dc.identifier.uri	https://hdl.handle.net/10550/80592
dc.description.abstract	Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.
dc.language.iso	eng
dc.relation.ispartof	Science, 2021, vol. 374, p. 182-188
dc.subject	Arqueologia
dc.title	Ten millennia of hepatitis B virus evolution
dc.type	journal article	es_ES
dc.date.updated	2021-10-27T08:21:44Z
dc.identifier.idgrec	148438
dc.rights.accessRights	open access	es_ES