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High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms

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High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms

dc.contributor.author	Nazir, Yasir
dc.contributor.author	Linsaenkart, Pichchapa
dc.contributor.author	Khantham, Chiranan
dc.contributor.author	Chaitep, Tanakarn
dc.contributor.author	Jantrawut, Pensark
dc.contributor.author	Chittasupho, Chuda
dc.contributor.author	Rachtanapun, Pornchai
dc.contributor.author	Jantanasakulwong, Kittisak
dc.contributor.author	Phimolsiripol, Yuthana
dc.contributor.author	Sommano, Sarana Rose
dc.contributor.author	Tocharus, Jinaporn
dc.contributor.author	Mingmalairak, Salin
dc.contributor.author	Wongsa, Anchali
dc.contributor.author	Arjin, Chaiwat
dc.contributor.author	Sringarm, Korawan
dc.contributor.author	Berrada Ramdani, Houda
dc.contributor.author	Barba Orellana, Francisco José
dc.contributor.author	Ruksiriwanich, Warintorn
dc.date.accessioned	2022-04-04T09:45:59Z
dc.date.available	2022-04-04T09:45:59Z
dc.date.issued	2021
dc.identifier.citation	Nazir, Yasir Linsaenkart, Pichchapa Khantham, Chiranan Chaitep, Tanakarn Jantrawut, Pensark Chittasupho, Chuda Rachtanapun, Pornchai Jantanasakulwong, Kittisak Phimolsiripol, Yuthana Sommano, Sarana Rose Tocharus, Jinaporn Mingmalairak, Salin Wongsa, Anchali Arjin, Chaiwat Sringarm, Korawan Berrada, Houda Barba Orellana, Francisco José Ruksiriwanich, Warintorn 2021 High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms Journal Of Fungi 7 12 1 18
dc.identifier.uri	https://hdl.handle.net/10550/82142
dc.description.abstract	Dictyophora indusiata or Phallus indusiatus is widely used as not only traditional medicine, functional foods, but also, skin care agents. Biological activities of the fruiting body from D. indusiata were widely reported, while the studies on the application of immature bamboo mushroom extracts were limited especially in the wound healing effect. Wound healing process composed of 4 stages including hemostasis, inflammation, proliferation, and remodelling. This study divided the egg stage of bamboo mushroom into 3 parts: peel and green mixture (PGW), core (CW), and whole mushroom (WW). Then, aqueous extracts were investigated for their nucleotide sequencing, biological compound contents, and wound healing effect. The anti-inflammatory determination via the levels of cytokine releasing from macrophages, and the collagen stimulation activity on fibroblasts by matrix metalloproteinase-2 (MMP-2) inhibitory activity were determined to serve for the wound healing process promotion in the stage 2-4 (wound inflammation, proliferation, and remodelling of the skin). All D. indusiata extracts showed good antioxidant potential, significantly anti-inflammatory activity in the decreasing of the nitric oxide (NO), interleukin-1 (IL-1), interleukin-1 (IL-6), and tumour necrosis factor-α (TNF-α) secretion from macrophage cells (p < 0.05), and the effective collagen stimulation via MMP-2 inhibition. In particular, CW extract containing high content of catechin (68.761 ± 0.010 mg/g extract) which could significantly suppress NO secretion (0.06 ± 0.02 µmol/L) better than the standard anti-inflammatory drug diclofenac (0.12 ± 0.02 µmol/L) and their MMP-2 inhibition (41.33 ± 9.44%) was comparable to L-ascorbic acid (50.65 ± 2.53%). These findings support that CW of D. indusiata could be an essential natural active ingredient for skin wound healing pharmaceutical products.
dc.language.iso	eng
dc.relation.ispartof	Journal Of Fungi, 2021, vol. 7, num. 12, p. 1-18
dc.subject	Química farmacèutica
dc.title	High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms
dc.type	journal article	es_ES
dc.date.updated	2022-04-04T09:45:59Z
dc.identifier.doi	10.3390/jof7121100
dc.identifier.idgrec	151114
dc.rights.accessRights	open access	es_ES