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Prevalence of pathogenic copy number variants among children conceived by donor oocyte

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Prevalence of pathogenic copy number variants among children conceived by donor oocyte

dc.contributor.author	Monfort Membrado, Sandra
dc.contributor.author	Orellana Alonso, Carmen
dc.contributor.author	Oltra Soler, Juan Silvestre
dc.contributor.author	Roselló Piera, Mónica Pilar
dc.contributor.author	Caro-Llopis, Alfonso
dc.contributor.author	Martínez Castellano, Francisco
dc.date.accessioned	2022-04-13T13:48:45Z
dc.date.available	2022-04-13T13:48:45Z
dc.date.issued	2021
dc.identifier.citation	Monfort Membrado, Sandra Orellana Alonso, Carmen Oltra Soler, Juan Silvestre Roselló Piera, Mónica Pilar Caro-Llopis, Alfonso Martínez Castellano, Francisco 2021 Prevalence of pathogenic copy number variants among children conceived by donor oocyte Scientific Reports 11 6752
dc.identifier.uri	https://hdl.handle.net/10550/82346
dc.description.abstract	Development of assisted reproductive technologies to address infertility has favored the birth of many children in the last years. The majority of children born with these treatments are healthy, but some concerns remain on the safety of these medical procedures. We have retrospectively analyzed both the fertilization method and the microarray results in all those children born between 2010 and 2019 with multiple congenital anomalies, developmental delay and/or autistic spectrum disorder (n = 486) referred for array study in our center. This analysis showed a significant excess of pathogenic copy number variants among those patients conceived after in vitro fertilization with donor oocyte with respect to those patients conceived by natural fertilization (p = 0.0001). On the other hand, no significant excess of pathogenic copy number variants was observed among patients born by autologous oocyte in vitro fertilization. Further studies are necessary to confirm these results and in order to identify the factors that may contribute to an increased risk of genomic rearrangements, as well as consider the screening for genomic alterations after oocyte donation in prenatal diagnosis.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2021, vol. 11, num. 6752
dc.subject	Genètica
dc.subject	Patologia
dc.title	Prevalence of pathogenic copy number variants among children conceived by donor oocyte
dc.type	journal article	es_ES
dc.date.updated	2022-04-13T13:48:45Z
dc.identifier.doi	10.1038/s41598-021-86242-x
dc.identifier.idgrec	151534
dc.rights.accessRights	open access	es_ES